Background: There has been scarce information about clear cell adenocarcinoma of the urethra (CCAU), an extremely rare type of cancer. A few case reports show that CCAU tends to have similar clinical manifestation to the other urethral carcinomas, urethrocystoscopy can easily identify tumoral lesions in the urethra, and bloody drainage from the urethral meatus is often seen during physical exams.Methods: A 52-year-old woman presented with dysuria for 6 months. Urethrocystoscopy did not reveal abnormality, and there was no bloody vaginal drainage or bloody drainage from the urethral meatus during physical exams. Ultrasonography demonstrated a solid mass with well-defined margins located between the anterior vaginal wall and the posterior urethral wall. Computed tomography showed the mass with smooth margins at the level of vaginal fornix, and magnetic resonance imaging showed the same location of the tumor as ultrasonography.Results: Surgical removal of the tumor was successfully performed and histological and immunohistochemical analysis confirmed the final diagnosis of CCAU.Conclusion: Abnormality in urethrocystoscopy and bloody drainage during the physical exam were not found in this case, which is in contrast to the findings reported in literature. These unusual features add new knowledge about CCAU that deserves dissemination for improved CCAU diagnosis and management.J Clin Med Res. 2018;10(8):665-667doi: https://doi.org/10.14740/jocmr3500w.
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机译：背景：关于尿道透明细胞腺癌（CCAU）的信息很少，这是一种极为罕见的癌症。一些病例报告显示，CCAU往往具有与其他尿道癌相似的临床表现，尿道膀胱镜检查可以轻松识别尿道中的肿瘤病变，并且在体格检查中经常看到尿道口有血性引流。方法：52岁老妇出现排尿困难6个月。尿道膀胱镜检查未发现异常，体格检查期间未见阴道流血或尿道口流血。超声检查显示为实性肿块，位于阴道前壁和尿道后壁之间的边缘清晰。计算机体层摄影术显示在阴道穹the处的肿块边缘光滑，磁共振成像显示与超声检查相同的肿瘤位置。结果：手术切除肿瘤成功，组织学和免疫组织化学分析证实了CCAU的最终诊断结论：在这种情况下未发现尿道膀胱镜检查异常和体格检查中的流血现象，这与文献报道的发现相反。这些非同寻常的功能增加了有关CCAU的新知识，值得传播以改善CCAU的诊断和管理。JClin Med Res。 2018; 10（8）：665-667doi：https://doi.org/10.14740/jocmr3500w。
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