Characteristic cardiac phenotypes are detected by cardiovascular magnetic resonance in patients with different clinical phenotypes and genotypes of mitochondrial myopathy

摘要

BackgroundMitochondrial myopathies (MM) are a heterogeneous group of inherited conditions resulting from a primary defect in the mitochondrial respiratory chain with consecutively impaired cellular energy metabolism. Small sized studies using mainly electrocardiography (ECG) and echocardiography have revealed cardiac abnormalities ranging from conduction abnormalities and arrhythmias to hypertrophic or dilated cardiomyopathy in these patients. Recently, characteristic patterns of cardiac involvement were documented by cardiovascular magnetic resonance (CMR) in patients with chronic progressive external ophthalmoplegia (CPEO)/Kearns-Sayre syndrome (KSS) and with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS). The present study aimed to characterize the prevalence and pattern of cardiac abnormalities and to test the additional diagnostic value of CMR in this patient population. The hypothesis that different neuromuscular MM syndromes present with different cardiac disease phenotypes was evaluated.MethodsSixty-four MM patients (50?±?15?years, 44?% male) and 25 matched controls (52?±?14?years, 36?% male) prospectively underwent cardiac evaluations including CMR (comprising cine- and late-gadolinium-enhancement (LGE) imaging). Based on the neuromuscular phenotype and genotype, the patients were grouped: a) CPEO/KSS (N?=?33); b) MELAS/–like (N?=?11); c) myoclonic epilepsy with ragged-red fibers (MERRF) (N?=?3) and d) other non-specific MM forms (N?=?17).ResultsAmong the 64 MM patients, 34 (53?%) had at least one abnormal CMR finding: 18 (28?%) demonstrated an impaired left ventricular ejection-fraction (LV-EF <60?%), 14 (22?%) had unexplained LV hypertrophy and 21 (33?%) were LGE-positive. Compared to controls, MM patients showed significantly higher maximal wall thickness (10?±?3 vs. 8?±?2?mm, p?=?0.005) and concentricity (LV mass to end-diastolic volume: 0.84?±?0.27 vs. 0.67?±?0.11, p?