A bispecific chimeric antigen receptor molecule enhances T cell activation through dual immunological synapse formation and offsets antigen escape in glioblastoma

Meenakshi Hegde; Zakaria Grada; Antonella Pignata; Amanda Wakefield; Kristen Fousek; Kevin Bielamowicz; Kevin Chow; Vita Brawley; Tiara Byrd; Stephen Gottschalk; Malini Mukherjee; Winfried S Wels; Matthew Baker; Giapietro Dotti; Jordan Orange; Nabil Ahmed

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A bispecific chimeric antigen receptor molecule enhances T cell activation through dual immunological synapse formation and offsets antigen escape in glioblastoma

机译：双特异性嵌合抗原受体分子通过双重免疫突触形成增强T细胞活化并抵消胶质母细胞瘤中的抗原逃逸

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《Journal for ImmunoTherapy of Cancer》 |2015年第s2期|共页
作者
Meenakshi Hegde; Zakaria Grada; Antonella Pignata; Amanda Wakefield; Kristen Fousek; Kevin Bielamowicz; Kevin Chow; Vita Brawley; Tiara Byrd; Stephen Gottschalk; Malini Mukherjee; Winfried S Wels; Matthew Baker; Giapietro Dotti; Jordan Orange; Nabil Ahmed;
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中图分类肿瘤学;
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1. A BISPECIFIC CHIMERIC ANTIGEN RECEPTOR MOLECULE ENHANCES THE ANTI-GLIOBLASTOMA EFFICACY OFT CELLS THROUGH DUAL IMMUNOLOGICAL SYNAPSE FORMATION [J] . Hegde M., Mukherjee M., Grada Z., Cytotherapy . 2016,第6SSuppla期

机译：双特异性嵌合抗原受体分子通过双免疫突触形成增强了细胞的抗胶质母细胞瘤疗效
2. Dual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances antitumor activity and survival [J] . Genssler Sabrina, Burger Michael C., Zhang Congcong, Oncoimmunology. . 2016,第4期

机译：嵌合抗原受体工程化的自然杀伤细胞对胶质母细胞瘤的双重靶向克服了靶抗原表达的异质性并增强了抗肿瘤活性和存活率
3. Abbreviated T-Cell Activation on the Automated Clinimacs Prodigy Device Enhances Bispecific CD19/22 Chimeric Antigen Receptor T-Cell Viability and Fold Expansion, Reducing Total Culture Duration [J] . Srivastava Sandeep K., Panch Sandhya R., Jin Jianjian, Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：缩写型T细胞激活自动化的Clinimacs Prodigy Device增强双特异性CD19 / 22嵌合抗原受体T细胞活力并折叠膨胀，降低总培养持续时间
4. Main Issues and Current Strategies in Enhancing the Efficacy of Chimeric Antigen Receptor T-Cell Therapy among Tumor Treatments [C] . Zhengting He International Conference on Frontiers of Biological Sciences and Engineering . 2020

机译：提高嵌合抗原受体T细胞治疗肿瘤治疗疗效的主要问题及目前策略
5. T cell recognition of antigen: Immunological synapse formation, activation and differentiation [D] . Grakoui, Arash. 1999

机译：抗原的T细胞识别：免疫突触的形成，激活和分化
6. A bispecific chimeric antigen receptor molecule enhances T cell activation through dual immunological synapse formation and offsets antigen escape in glioblastoma [O] . Meenakshi Hegde, Zakaria Grada, Antonella Pignata, 2015

机译：双特异性嵌合抗原受体分子通过双重免疫突触形成增强T细胞活化并抵消胶质母细胞瘤中的抗原逃逸
7. A bispecific chimeric antigen receptor molecule enhances T cell activation through dual immunological synapse formation and offsets antigen escape in glioblastoma [O] . 2015

机译：双特异性嵌合抗原受体分子通过双重免疫突触形成增强T细胞活化并抵消胶质母细胞瘤中的抗原逃逸

A bispecific chimeric antigen receptor molecule enhances T cell activation through dual immunological synapse formation and offsets antigen escape in glioblastoma

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