antibody, antigen binding fragment of an antibody, chimeric molecule, chimeric antigen receptor, polynucleotide, cell, methods for preparing chimeric antigen receptor, for making an antibody, and for determining the presence of cd127 + cells, pharmaceutical composition, medium combination therapy, diagnostic method, and use of an anti-cd127 antibody or antigen-binding fragment thereof

摘要

The invention relates to humanized antibodies directed against the extracellular domain of the interleukin 7 (il-7) receptor alpha chain, especially against the human il-7 receptor expressed in human cells (also called human 7ralfa or il-7ra). or cd127) and does not interfere with the il-7 or tslp signaling pathways. The antibodies of the invention have no il-7 receptor antagonistic effect, but may still exhibit cytotoxic activity against cd127 positive cells. In a particular embodiment, the antibody has no agonistic effect on the il-7 receptor.