Ex vivo conditioning with IL-12 decreases T cell sensitivity to intratumoral INF-γ-induced apoptosis following adoptive transfer

C Marcela Diaz-Montero; Charles Tannenbaum; Patricia Rayman; Paul Pavicic; Jin Sub Kim; Marc Ernstoff; James Finke

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Ex vivo conditioning with IL-12 decreases T cell sensitivity to intratumoral INF-γ-induced apoptosis following adoptive transfer

机译：IL-12的离体调理降低了过继转移后T细胞对肿瘤内INF-γ诱导的细胞凋亡的敏感性

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《Journal for ImmunoTherapy of Cancer》 |2015年第s2期|共页
作者
C Marcela Diaz-Montero; Charles Tannenbaum; Patricia Rayman; Paul Pavicic; Jin Sub Kim; Marc Ernstoff; James Finke;
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中图分类肿瘤学;
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1. IL-12 stimuli during ex vivo expansion not only prevents the upregulation of PD1 on tumor infiltrating adoptively transferred T cells but also on endogenous TILs which results in effective tumor regression [J] . C Marcela Diaz-Montero, Yu Yang, Patricia A Rayman, Journal for ImmunoTherapy of Cancer . 2014,第S3期

机译：离体扩增期间的IL-12刺激不仅可以防止PD1在肿瘤浸润的过继转移T细胞上的上调，而且还可以防止内源性TIL上的PD1上调，从而有效地消退肿瘤
2. γδT Cells Positively Regulate Contact Sensitivity (CS) Reaction via Modulation of INF-γ, IL-12 and TNF-α Production [J] . Strzepa A., Majewska-Szczepanik M., Szczepanik M. Folia Biologica: A Quarterly Journal of Biological Research . 2013,第3a4期

机译：γδT细胞通过调节INF-γ，IL-12和TNF-α产生正向调节接触敏感性（CS）反应
3. Significant anti-tumour activity of adoptively transferred T cells elicited by intratumoral dendritic cell vaccine injection through enhancing the ratio of CD8(+) T cell/regulatory T cells in tumour. [J] . Song S, Zhang K, You H, Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology . 2010,第1期

机译：通过提高肿瘤中CD8（+）T细胞/调节性T细胞的比例，通过瘤内树突状细胞疫苗注射引发的过继转移T细胞具有显着的抗肿瘤活性。
4. M2-A, A Novel Amonafide Analogue, Induces Apoptosis and G2-M Arrest via Decreasing Topoisomerase LIa Activity and Inhibits PI3K/Akt Pathway on HL60 Cells [C] . The 12th Asian Pacific Confederation of Chemical Engineering Congress(第十二届亚太化工联盟大会暨化工展览会)论文集 . 2008

机译：M2-A，一种新颖的阿莫那肽类似物，通过降低拓扑异构酶LIa活性诱导HL60细胞凋亡和G2-M逮捕并抑制PI3K / Akt途径。
5. Enhancing adoptive T cell transfer therapies: Novel treatments through IL-12 CD8 T cell priming and adjunctive use of a histone deacetylase inhibitor [D] . Lisiero, Dominique Naomi 2012

机译：增强过继性T细胞转移疗法：通过IL-12 CD8 T细胞启动和组蛋白脱乙酰基酶抑制剂的辅助使用的新疗法
6. Ex vivo conditioning with IL-12 decreases T cell sensitivity to intratumoral INF-γ-induced apoptosis following adoptive transfer [O] . C Marcela Diaz-Montero, Charles Tannenbaum, Patricia Rayman, 2015

机译：IL-12的离体调理降低了过继转移后T细胞对肿瘤内INF-γ诱导的细胞凋亡的敏感性
7. Ex vivo conditioning with IL-12 decreases T cell sensitivity to intratumoral INF-γ-induced apoptosis following adoptive transfer [O] . 2015

机译：IL-12的离体调理降低了过继转移后T细胞对肿瘤内INF-γ诱导的细胞凋亡的敏感性

Ex vivo conditioning with IL-12 decreases T cell sensitivity to intratumoral INF-γ-induced apoptosis following adoptive transfer

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