IL-12 stimuli during ex vivo expansion not only prevents the upregulation of PD1 on tumor infiltrating adoptively transferred T cells but also on endogenous TILs which results in effective tumor regression

C Marcela Diaz-Montero; Yu Yang; Patricia A Rayman; Alberto Montero; Charlie Tannenbaum; James Finke

首页> 外文期刊>Journal for ImmunoTherapy of Cancer >IL-12 stimuli during ex vivo expansion not only prevents the upregulation of PD1 on tumor infiltrating adoptively transferred T cells but also on endogenous TILs which results in effective tumor regression

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IL-12 stimuli during ex vivo expansion not only prevents the upregulation of PD1 on tumor infiltrating adoptively transferred T cells but also on endogenous TILs which results in effective tumor regression

机译：离体扩增期间的IL-12刺激不仅可以防止PD1在肿瘤浸润的过继转移T细胞上的上调，而且还可以防止内源性TIL上的PD1上调，从而有效地消退肿瘤

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来源
《Journal for ImmunoTherapy of Cancer》 |2014年第s3期|共页
作者
C Marcela Diaz-Montero; Yu Yang; Patricia A Rayman; Alberto Montero; Charlie Tannenbaum; James Finke;
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中图分类肿瘤学;
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机译：过继转移的肿瘤浸润T细胞靶向人乳头瘤病毒+癌症患者的体细胞癌突变，具有完全的肿瘤消退
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3. CXCL10-induced migration of adoptively transferred human natural killer cells toward solid tumors causes regression of tumor growth in vivo [J] . Wennerberg Erik, Kremer Veronika, Childs Richard, Cancer immunology, immunotherapy : . 2015,第2期

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4. Modulation of tumor response to photodynamic therapy in severe combined immunodeficient (SCID) mice by adoptively transferred lymphoid cells [C] . Mladen Korbelik, British Columbia Cancer Agency, Vancouver, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V . 1996

机译：过继转移淋巴样细胞对重度联合免疫缺陷（SCID）小鼠对光动力疗法的肿瘤反应的调节
5. Tumor Infiltrating Lymphocyte Therapy for Renal Cell Carcinoma: Methods for ex vivo Expansion and T-Cell Memory Induction [D] . Braun, Mitchell W. 2021

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6. IL-12 stimuli during ex vivo expansion not only prevents the upregulation of PD1 on tumor infiltrating adoptively transferred T cells but also on endogenous TILs which results in effective tumor regression [O] . C Marcela Diaz-Montero, Yu Yang, Patricia A Rayman, 2014

机译：离体扩增期间的IL-12刺激不仅可以防止PD1在肿瘤浸润的过继转移T细胞上的上调而且还可以防止内源性TIL上的PD1上调从而有效地消退肿瘤
7. IL-12 stimuli during ex vivo expansion not only prevents the upregulation of PD1 on tumor infiltrating adoptively transferred T cells but also on endogenous TILs which results in effective tumor regression [O] . C Diaz-Montero, Yu Yang, Patricia A Rayman, 2014

机译：离体扩增期间的IL-12刺激不仅可以防止PD1在肿瘤浸润的过继转移T细胞上的上调，而且还可以防止内源性TIL上的PD1上调，从而有效地消退肿瘤
8. Preparation for a Clinical Trial Using Adoptive Transfer of Tumor- Reactive TGF-Beta-Insensitive CD8+ T Cells for Treatment of Prostate Cancer [R] . Lee, C. 2006

机译：使用过继转移肿瘤反应性TGF-β不敏感CD8 + T细胞治疗前列腺癌的临床试验准备

IL-12 stimuli during ex vivo expansion not only prevents the upregulation of PD1 on tumor infiltrating adoptively transferred T cells but also on endogenous TILs which results in effective tumor regression

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