• 主题
高级搜索  >
历史搜索 清空历史
您现在的位置：首页> 中文期刊>外科学>医药卫生>中华内分泌外科杂志

中华内分泌外科杂志

中华内分泌外科杂志

CSTPCD

Journal of Endocrine Surgery
中国科学技术协会主管，中华医学会主办，重庆医科大学附属第一医院承办。本刊自2002年试刊，2008年正式更名。设有述评、实验研究、临床研究、临床报道、专家讲座、综述等栏目。主要内容涉及内分泌外科学的基础理论；内分泌外科疾病的临床和实验研究等。本刊秉承以临床为主，基础为辅的办刊方针，着力于传播内分泌外科的新理论、新进展、新技术，力求打造内分泌外科学术研究与交流的良好平台，成为一本反映内分泌外科研究成果和发展动向的高质量的精品医学专业学术期刊。
更多
  • 发文量：2208
  • 被引量：766
  • H指数：1
  • 开始收录时间：2007,1(1)
  • CNKI综合因子：0.613
  • 维普期刊影响因子： 0.939
  • 万方期刊影响因子：1.11
  • 创刊时间：2007
  • 国内刊号/CN：11-5807/R
    国际刊号/ISSN：1674-6090
  • 发行周期：双月刊
    邮发代号：78-165
  • 主管单位：中国科学技术协会
    主办单位：中华医学会
中华内分泌外科杂志-联系信息
  • 主编：-
  • 电话：023-89012705
  • 邮箱：nfmwk2705@163.com
  • 地址：重庆市渝中区袁家岗友谊路1号
  • 邮编：400016
中华内分泌外科杂志-获奖情况
  • 暂无获奖信息
  • 收录汇总
  • 刊内文献检索
  • 投稿信息

刊期浏览

相关中文期刊

相关中文会议

相关外文期刊

相关外文会议

最新期刊

热门期刊

中华内分泌外科杂志 >2021年第6期

学科

年度

全选（0）
排序：
共4384条结果
  • 摘要：胰腺神经内分泌肿瘤(PNET)是一类极其复杂且高度异质性的肿瘤,近年来发病率呈逐年上升趋势.日前对于PNET的研究远远滞后于其他类型,因此更好地明确PNET的分子病理特点对于其诊断、治疗和预后改善具有重要意义.随着分子生物学技术的发展,PNET分子病理学机制的研究逐步深入,有望为PNET的治疗带来新的思路.本文将对PNET的分子病理学研究进展进行综述.%Pancreatic neuroendoerine tumors (PNET) is a complicated and heterogeneous group of neoplasia,and the incidence of PNET is growing rapidly recently.The current study on PNET lags behind what is known of other pancreatic tumors.Therefore,understanding of the molecular pathology is important for improving the early diagnosis,treatment and prognosis.With the development of molecular biology,there are already several potential targets proved to have application role in treatment of PNET.Here,the authors present the current knowledge about the molecular alterations of PNET.
  • 摘要：Objective To establish the pancreatic cancerogenesis model in mice and to observe the changes of the immune cell populations in peripheral blood and pancreatic lesions.Methods The in situ embedding of canerogen dimethylbenzanthracene (DMBA) was adopted to establish the pancreatic cancerogenesis process from chronic pancreatitis(CP),pancreatic intraepithelial neoplasma (PanIN) to pancreatic cancer.Total ly 60 C57BL/6J mice were used,and 8 weeks after embedding,the mice were killed.20 mice were randomized selected,and 7 immune cell populations in the peripheral blood and pancreatic lesions were detected by flow cytometery(FCM).Results During the observational peroid of 8 weeks,14(23.3％) mice died.Among the 46 survivors,20 mice were randomized selected for FCM analysis.All of the 46 pancreatic lesions were pathologically analyzed.12 cases were CP(26.1％),11 cases were lower grade PanIN (PanIN-1,2,LG-PanIN) (23.9％),9 cases were high grade PanIN (PanIN-3,HG-PanIN) (19.6％) and 14 cases were PC.Among the 20 randomized selected mice,4 cases were CP,7 cases were LG-PanIN,4 cases were HG-PanIN and 5 cases were PC.The myeloid derived suppressor cells (MDSC) of HG-PanIN and CP were significantly more than that of LG-PanIN and CP.In the pancreatic lesions,the granulocytes,MDSC and M2 polarized TAM of HG-PanIN and PC were significantly more than that of LG-PanIN and CP.On the contrary,the T lymphocytes and M1 polarized TAM were significantly decreased.Conclusions In situ embedding of DMBA is a feasible and practical method to establish the spontaneous pancreatic cancerogenesis model in the immunocompetent mice.Pancreatic cancerogenesis can induce systemic and even stronger local immunosuppression,and the MDSC and M2 polarized TAM may play the vital roles.%目的 建立小鼠胰腺癌发生模型并观察外周血及肿瘤组织中免疫细胞群的变化.方法 利用致癌剂二甲基苯蒽(DMBA)胰腺内原位包埋的方法建立从慢性胰腺炎(chronic pancreatitis,CP)、胰腺导管内瘤变(pancreatic intraepithelial neoplasma,PanIN)到胰腺癌(pancreatic cancer,PC)的发生模型.共建模60只,8周后处死小鼠.随机选择20只存活小鼠,利用流式细胞计数技术(flow cytometry,FCM)检测外周血及胰腺病变组织中7个免疫细胞群的变化.结果 建模8周内共死亡14只(23.3％),存活46只.46只小鼠病变胰腺组织均制备石蜡切片行常规HE染色.46个病变组织中,12例CP(26.1％),11例低级别PanIN (low grade-PanIN,PanIN-1,2,LG-PanIN)(23.9％),9例高级别PanIN(high grade-PanIN,PanIN-3,HG-PanIN)(19.6％)及14例PC (30.4％).随机选择的20只小鼠中,PC及HG-PanIN小鼠外周血中髓系来源抑制细胞(myeloid derived suppressor cells,MDSC)明显高于LG-PanIN及CP小鼠.PC及HG-PanIN小鼠胰腺病变组织中粒细胞、MDSC及M2型肿瘤相关巨噬细胞(tumor associated macrophages,TAM)较LG-PanIN及CP小鼠明显升高,而T淋巴细胞及M1型TAM明显减少.结论 利用DMBA胰腺内原位包埋是建立小鼠胰腺癌发生模型的简便易行的方法.胰腺癌在发生过程中,伴随全身及局部的免疫抑制效应,以病变组织内尤为明显,其中MDSC及M2型TAM可能起到关键作用.
  • 摘要：目的 探讨宫腔镜诊断绝经前后异常子宫流血的临床价值及安全性.方法 回顾性分析2010年1月至2015年1月因异常子宫出血于重庆市长寿区人民医院妇产科行宫腔镜检查的272例患者的临床特点及组织病理学资料.结果 组织病理学诊断子宫内膜息肉75例,其中5例镜下误诊为子宫黏膜下肌瘤,镜下诊断符合率为93.3％ (70/75);子宫黏膜下肌瘤50例,符合率为90.9％(50/55);子宫内膜增生症97例,其中7例镜下误诊为不典型增生或癌,符合率92.8％ (90/97);不典型增生或子宫内膜癌19例,符合率为73.1％(19/26);萎缩性子宫内膜23例;宫内节育环残留8例.结论 绝经前女性以子宫内膜增生、子宫黏膜下肌瘤、子宫内膜息肉为主,子宫内膜癌及癌前病变少见;而绝经后女性主要以子宫内膜息肉、萎缩性子宫内膜、癌及癌前病变为主.宫腔镜对常见的子宫内膜病变具有良好诊断价值,宜同时配合组织病理学检查.%Objective To evaluate the clinical value and safety of hysteroscopy in diagnosis of abnormal uterine bleeding.Methods The clinical characters and histopathological data of 272 cases of abnormal uterine bleeding were retrospectively analyzed.They received hysteroscopy in our hospital from Jan.2010 to Jan.2015.Results Histopathological diagnosis showed 75 cases were with endometrial polyps,including 5 cases misdiagnosed as submucosal fibroids,and the correct diagnostic rate was 93.3％ (70/75).50 cases were with submucosal fibroids,and the diagnostic rate was 90.9％ (50/55).97 cases were endometrial hyperplasia,including 7 cases misdiagnosed as atypical hyperplasia or cancer by hysteroscopy,and the correct diagnostic rate was 92.8％ (90/97).19 cases were atypical hyperplasia or endometrial carcinoma,and the diagnostic rate was 73.1％(19/26).Atrophic endometrium were 23 cases.8 cases had intrauterine device remained.Conclusions Premenopausal women are more likely to present with endometrial hyperplasia,submucosal fibroids,endometrial polyps,while endometrial cancer and precancerous lesions are rare.But in postmenopausal women endometrial polyps,atrophic endometrium,cancer and precancerous lesions are mainly included.Hysteroscopic has a good diagnostic value in endometrial diseases which should be combined with histopathological examination.
  • 摘要：随着内分泌检查的开展、影像学仪器的升级等,肾上腺皮质肿瘤诊治目前已从症状为导向的诊断性治疗向功能为导向的精确治疗逐渐过渡.意外腺瘤的发病率在人群高达7％,合并亚临床库欣时,手术切除可改善患者预后.原发性醛固酮增多症患者行病理组织功能鉴定有助于预后判断.肾上腺皮质癌的患者综合治疗推荐尽可能完整的肿瘤切除,对于不适宜手术患者推荐米托坦联合依托泊苷、阿霉素和顺铂作为一线化疗方案,而术后辅助放疗还需进一步研究.%Management of adrenocortical tumor are developing vigorously,from diagnostic treatment to precisely therapy with endocrine lab test and radiology examination improving.The prevalence rate of incidental adrenal mass is 7％.Update researches show that surgical treatment is beneficial in subclinical hypercorisolism patients combined with adrenal incidentaloma.Histopathology improves the evaluation of prognosis in primary aldosteronism patients.For adrenocortical cancer patients,mitotane with combination of etoposide,doxorubicin and cisplatin after surgical treatment was recommended,while adjuvant radiotherapy needs more study to conform the efficacy.
  • 摘要：目的 观察中药补肾健脾方对T2DM小鼠脑组织中炎症因子及铁代谢mRNA表达的影响.方法 将清洁级12周龄雄性C57BL/6小鼠30只按配对比较法随机分为正常对照组(5只)和高脂饲料喂养组(25只).高脂饲料喂养4周后腹腔注射链脲佐菌素(STZ,30 mg/kg).1d后取尾静脉血测随机血糖,血糖＞16.7 mmol/L即造模成功.血糖不达标者追加1次STZ,继续取尾静脉血测随机血糖.共有19只小鼠造模成功,按配对比较法随机分为糖尿病组(10只)和补肾健脾方组(9只).补肾健脾方组以7.4 g/kg·d灌胃,对照组灌服相同容积生理盐水.8周后取3只小鼠脑组织做病理切片,余小鼠脑组织分大脑、小脑、脑干、海马4部分,用RT-PCR检测炎症因子及铁代谢mRNA的表达.结果 ①糖尿病组小鼠大脑、海马中炎症因子白介素-6(IL-6)、白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)mRNA表达增加,差异有统计学意义(P＜0.01);铁代谢相关基因二价金属离子转运体(DMT1)mRNA表达升高,差异有统计学意义(P＜0.01);铁泵蛋白(FPN1)、铜蓝蛋白(CP)mRNA表达下降,差异有统计学意义(P＜0.01);脑组织病理切片见神经元丢失、退变及胶质细胞增生.②中药补肾健脾方干预后小鼠大脑、海马中炎症因子IL-6、IL-1β、TNF-α mRNA表达水平下降,差异有统计学意义(P＜0.01);DMT1 mRNA表达下降,FPN1、CP mRNA表达升高,差异有统计学意义(P＜0.01);小鼠脑组织切片中神经元丢失、退变及胶质细胞增生现象改善.结论 中药补肾健脾方干预可通过调节炎症因子及铁代谢mRNA的表达,改善T2DM小鼠脑组织神经元退变.%Objective To evaluate the effect of Jian Pi Bu Shen prescription on inflammatory factors and iron metabolism in the brain of T2DM model mice.Methods A total number of 30 healthy 12-week-old male mice were used in the present study.The groups were randomly assigned to one of the following experimental groups:(1) control group:n=5,the mice were maintained on a normal diet for 4 weeks;(2) model group:n=25,the mice were maintained a high fat diet for 4 weeks.Then,the mice were deprived of food for 12 hours before a single intraperitoneal injection of streptozotocin (STZ,30 mg/kg).Then,the blood glucose levels were measured randomly 3 times within 24 hours after injection.The mice whose blood glucose was less than 16.7 mmol/l would receive another single intraperitoneal injection of STZ.Finally,we got a total number of 19 mice meeting the criteria of animal model we described above.The final 19 mice were randomized to 2 groups:diabetes group (n=10)and Jian Pi Bu Shen (JPBS) group(n=9).JPBS group received gavage administration of JPBS Prescription 7.4 g/kg/d(8weeks).Diabetes group and control group were maintained treated with saline for 8 weeks.Mice were decapitated 24 hours after the last drug treatment.The mice brain tissue slices were prepared for pathological observation.To examine the effects of JPBS prescription on neuroinflammation and iron metabolism in cerebrum and hippocampi,the relative mRNA levels of IL-6,IL-1β,DMT1,FPN1 and CP were tested by RT-PCR.Results mRNA levels of IL-6,IL-1β and DMT1 in the brains of diabetes group were higher while the levels of FPN1 and CP were lower than that of the control group (P＜0.01).Compared with diabetes group,in JPBS group,mRNA levels of IL-6,IL-1β and DMTl in cerebrum and hippocampi were decreased while the levels of FPN1 and CP were increased (P＜0.01).The brain tissue slices of diabetes group showed neuron loss and signs of neurodegeneration.But JPBS group attenuated neurodegenerative change.Conclusion JPBS prescription can protect neuron from apoptosis,suppress neuroinflammation and attenuate iron metabolism,which may be one of the mechanisms of traditional Chinese medicine in treating cognitive dysfunction.
  • 摘要：目的 探讨可溶性CD30/CD30L和CD40/CD40L系统失衡在卵巢浆液性肿瘤中的临床意义.方法 选择浆液性囊腺瘤40例和浆液性囊腺癌30例,另选择年龄和体质量匹配的健康妇女30例作为对照.于术前和术后第7天分别抽取卵巢浆液性肿瘤患者和对照组外周静脉血3 ml,分离血清,用酶联免疫吸附法(ELISA)检测血清中可溶性CD30(sCD30)、sCD30L、sCD40和sCD40L水平.结果 与对照组相比,浆液性囊腺瘤和浆液性囊腺癌患者血清中sCD30、sCD30L、sCD40和sCD40L水平均显著升高,差异有统计学意义(P＜0.05);且浆液性囊腺癌较浆液性囊腺瘤患者进一步升高,差异有统计学意义(P＜0.05).浆液性囊腺瘤和浆液性囊腺癌患者术后第7天,血清中相应可溶性蛋白水平均较术前有显著降低,差异有统计学意义(P＜0.05).结论 检测血清sCD30/sCD30L和sCD40/sCD40L可能对卵巢肿瘤的早期诊断标志及术后病情转归有一定的指导意义.%Objective To investigate clinical significance of soluble CD30/CD30L and CD40/CD40L system imbalance in ovarian serous tumors.Methods 40 patients of serous cystadenoma and 30 patients of serous cystadenocarcinoma were selected,and 40 age-and weight-matched healthy women were also recruited as the control group.Peripheral venous blood (3 ml) of the healthy control and patients with ovarian serous tumors before surgery and 7 days after surgery were collected.After separation of serum,ELISA was used to detect levels of sCD30,sCD30L,sCD40 and sCD40L.Results Compared to the control group,levels of sCD30,sCD30L,sCD40 and sCD40L in both serous cystadenoma and serous cystadenocarcinoma groups were significantly in creased (P＜0.05).And in those serous cystadenocarcinoma group,levels of such soluble proteins were much higher than in serous cystadenoma group (P＜0.05).7 days after surgery,levels of such soluble proteins were significantly decreased in both serous cystadenoma and serous cystadenocarcinoma groups (P＜0.05).Conclusion Detection of serum sCD30/sCD30L and sCD40/sCD40L is possible to have a certain guiding significance to early diagnosis of ovarian tumors and the prognosis of patients.
  • 摘要：Objective To investigate the relationship between the expression of Pin1 and Ki67 and the clinicopathologic features of gastrointestinal stromal tumors (GIST).Methods 40 paraffin-embeded specimens of surgical resected GIST from Jan.2013 to May.2015 in Pathology Department of Yuhuangding Hospital Affiliated to Qingdao University were retrieved and expressions of Pin1 and Ki67 were detected by immunohistochemical methods.Results The positivity rate of Pin1 and Ki67 in GIST was 80％ and 32.5％ respectively.The expression of Pin1 was associated with malignancy of GIST,tumor location,tumor size and mitotic counts.The expression of Ki67 is associated with malignancy of GIST,tumor location,tumor size,mitotic counts and tumour necrosis.Pin1 expression was positively related with Ki67 expression.Conclusion Pin1 and Ki67 is closely related with malignancy of GIST,which may be potential factors in predicting prognosis of GIST.%目的 探讨Pin1和Ki67的表达与胃肠间质瘤(GIST)临床病理特征的关系.方法 收集烟台毓璜顶医院2013年1月至2015年5月间手术切除的40例GIST标本,采用免疫组化技术检测Pin1和Ki67的表达.结果 40例GIST标本中Pin1和Ki67的阳性率分别为80％(32/40)和32.5％(13/40).Pin1的表达程度与GIST的危险度、肿瘤部位、肿瘤大小、核分裂象相关(P＜0.05).Ki67的表达程度与GIST的危险度、肿瘤部位、肿瘤大小、核分裂象、肿瘤坏死相关(P＜0.05).Pin1的表达与Ki67的表达呈正相关(r=0.371,P＜0.05).结论 Pin1、Ki67可作为评价GIST恶性程度的潜在指标.Pin1对于GIST可能是一个很有潜力的预后指标和治疗靶点.
  • 摘要：Diabetic foot is one of the chronic complications of diabetes,which has great harm.Through active treatment such as anti-infection,debridement,surgical intervention,amputation rate can be declined.%糖尿病足作为糖尿病慢性并发症之一,危害极大,虽然目前通过积极的抗感染、清创、外科介入后,截肢率有所下降,但仍然普遍存在.
  • 摘要：Objective To investigate the effects of Sirtuin 1 (SIRT1) on expression and activity of islet endothelial cells (IEC) cultured by palmitic acid and high glucose.Methods Recombinant mouse SIRT1 plasmid including green fluorescent protein report gene was synthesized and transfected to islet endothelial cells using Lipofectamine 2000.Then,cells were treated by high level lipid with or without high level glucose for 48 hours.Cells in high glucose and lipid group were cultured in 33.3 mmol/L glucose and 0.5 mmol/L palmitic acid for 48 hours.Cells in high lipid group were cultured in 0.5 mmol/L palmitic acid for 48 hours.Western blot was used to test the transfecting efficacy of SIRTl recombinant plasmid.Real time quantitative-PCR and Western blot were used to exam the expression of endothelial nitric synthases(eNOS) mRNA and protein,respectively.Nitric oxide reductase method was used to test NO level in supernatant of cell culture.Results Compared with the control group,there was no change on eNOS mRNA and protein level in high lipid group;however,the expression of eNOS mRNA and protein level decreased significantly in cells cultured in high level lipid and glucose group.SIRT1 overexpression increased the protein level of eNOS in high lipid group,and also increased mRNA and protein level in high lipid and glucose group.Compared with the control group,NO decreased significantly in high level lipid cultured endothelial cells,and decreased further in high lipid and high glucose cultured group.SIRT1 overexpression increased NO not only in normal cells but also in high level lipid with or without high glucose cells.Conclusions SIRT1 improves the expression and activity of eNOS in IEC and can increase the release of NO by endothelial cells,which may be helpful in improving the function of islet beta cells.SIRT1 may have great promise in new medicine development,gene therapy and islet transplantation in diabetes.%目的 分析高表达组蛋白去乙酰化酶(sirtuin 1,SIRT1)对高糖高脂培养胰岛微血管内皮细胞(islet endothelial cells,IEC)内皮型一氧化氮合酶(eNOS)表达及活性的影响.方法 合成含绿色荧光蛋白报告基因的小鼠SIRT1基因重组质粒,以Lipofectamine 2000转染IEC后以高脂或高糖高脂处理48 h.高脂组以0.5 mmol/L棕榈酸处理;高脂高糖组以33.3 mmol/L葡萄糖+0.5 mmol/L棕榈酸处理.应用Western印迹法检测SIRT1基因转染效果;应用实时荧光定量PCR及Western印迹法检测eNOS的基因及蛋白水平;应用硝酸还原酶法检测培养细胞上清中NO的水平.结果 相对于正常对照组,高脂培养IEC eNOS基因及蛋白水平无明显变化;但高脂高糖环境下,eNOS的基因及蛋白水平明显下降.高表达SIRT1不仅可升高高脂培养内皮细胞eNOS蛋白表达,且可升高高脂高糖培养内皮细胞eNOS mRNA及蛋白表达.相对于正常对照组,高脂培养使内皮细胞分泌NO水平明显下降,高糖高脂培养使内皮细胞NO水平进一步下降,高表达SIRT1不仅可升高基础状态下内皮细胞的NO水平,且可升高高脂、高脂高糖培养内皮细胞的NO水平,差异具有统计学意义.结论 SIRT1可改善高糖高脂培养胰岛微血管内皮细胞的eNOS表达及活性,使内皮源性NO分泌增加,因而可能有助于改善胰岛B细胞功能,在糖尿病的药物开发、基因治疗及胰岛移植治疗中具有广阔的前景.
  • 摘要：胰腺神经内分泌肿瘤是一类少见肿瘤,近年有增加趋势.无论根治切除肿瘤还是降低肿瘤负荷,外科手术仍是主要手段.不同起源的疾病类型,不同部位的病灶,不同发展阶段的肿瘤,需要不同术式,也会产生不同疗效.由于临床表现多样,治疗方式和效果评价存在分歧,建议诊治在多学科协作模式下进行,个体化应用多种治疗手段,有望提高病人的预后.%Pancreatic neuroendocrine neoplasms (pNENs) are clinically rare,however,it shows an in creasing trend recent years.Surgical management,such as radical resection or debulking,plays an important role in this field.Different procedures can be applied to tumors with different types,locations,and developing stages.The optimal clinical management of pNENs involves a multidisciplinary approach in order to improve prognosis.
  • 摘要：Objective To discuss the diagnosis and inductive chemoradiotherapy of stage Ⅲ and stage Ⅳa invasive thymoma.Methods Clinical data of 13 cases with incomplete resected invasive thymoma were analyzed retrospectively,among which 8 cases were in stage Ⅲ and 5 cases in stage Ⅳa.All the 13 cases had invasion of major vessels,pericardial and lung tissues,or had metastasis of pleura and pericardium.Each patient got pathological diagnosis by fine needle aspiration,video-assisted thoracoscopic biopsy or anterior mediastinal biopsy.After 3 cycles of NP or CAP inductive chemotherapy and synchronous radiotherapy,tumors shrank and got palliative or complete surgical resection.The Follow up ranged from 2.8 to 9 years.Results All the 13 cases were malignant thymoma,including 4 cases of type B2,6 cases of type B3 and 5 cases of type C.7 patients got radical resection and 2 got palliative resection.9 patients survived more than 3 years after operation,7 patients survived more than 5 years,one patient even lived 8 years,and the other 4 patients without getting surgery died in 4 years.Conclusion Inductive chemoradiotherapy could shrink stage Ⅲ and stage Ⅳa invasive thymoma,reduce clinical stage,improve the resection rate,and prolong survival.%目的 探讨Ⅲ、Ⅳa期侵袭性胸腺瘤的诊断及术前诱导治疗策略.方法 回顾分析13例Ⅲ、Ⅳa期侵袭性胸腺瘤患者的临床资料,其中Ⅲ期8例,Ⅳa期5例.肿瘤均侵犯大血管、心包或肺组织,或胸膜、心包转移.所有患者均经带芯穿刺、胸腔镜或前纵膈切开活检确诊,经长春瑞滨+顺铂(NP)或环磷酰胺,表阿霉素,顺铂(CAP)方案术前诱导化疗3周期或同步放疗30 GY,肿瘤缩小、分期降低后行完全性或姑息性手术切除.均长期随访.结果 13例病理均为恶性胸腺瘤,其中B2型4例,B3型6例,C型3例.诱导化疗疗效评价,部分缓解(PR)9例,疾病稳定(SD)4例.根治性切除7例,姑息性切除2例.9例手术患者均存活超过3年,超过5年7例(77.7％),超过8年1例;4例未手术患者均在4年内死亡.结论 对于无法完全切除的Ⅲ、Ⅳa期侵袭性胸腺瘤,术前诱导治疗,可使原发肿瘤缩小,控制转移灶,降低临床分期,提高手术的完全切除率,有延长生存期的趋势.
  • 摘要：The epidermal stem cell was introduced briefly in this review.And then the spacial characteristics of diabetic wound healing were summarized.In this regards,we focus on the important role of epidermal stem cell in diabetic wound healing.At last,we outlook the research direction and clinical application of epidermal stem cell in diabetic wound.%本文概述表皮干细胞的生物学特点,总结糖尿病伤口的特殊性及不易愈合的原因,追踪表皮干细胞在糖尿病伤口修复中的研究进展,最后展望表皮干细胞技术对糖尿病皮肤伤口修复的研究方向.
  • 摘要：规范化的术后管理同样是甲状腺微小癌治疗的重要组成部分,包括初治期及随访期.初治期术后管理基于初治期复发风险分层,初治复发风险分层确立后可指导初治的TSH抑制治疗及RAI辅助治疗,并指导后续随访计划的制定,但初治复发风险分层作为一种静态病情评估,不能有效反映患者术后长时间状态变化.随访期术后管理应依据术后长期随访的所有资料对患者进行复发风险再分层.复发风险再分层确立后可指导TSH抑制治疗程度的调整、随访计划及相应治疗方案的制定.兼顾TSH抑制治疗副作用风险,根据双风险评估体系,制定TSH抑制目标值,以达到保证治疗效果同时,最大限度提升患者生活质量的目的.%The postoperative management of papillary thyroid microcarcinoma (PTMC) is one of the most important parts of management for PTMC,and it includes the initial management and long-term management of PTMC.The initial management of thyroid cancer is based on initial recurrence risk stratification system.The initial risk stratification system can be used to guide initial TSH suppression therapy,RAI assistant therapy and management of follow up.Initial risk assessment of recurrence,as a static representation of the patient in the first few weeks post-operatively,could not be continually updated during follow up.In order to account for the changes of the recurrence risk and disease specific mortality,re-stratification of risk should be performed during follow up,using all the clinical,biochemical,imaging (structural and functional),and cytopathologic findings obtained during follow up.Re-stratification of risk can inform clinicians on degree of ongoing TSH suppression,frequency and intensity of follow-up,and need for additional therapies were recommended in guideline.Adjustment of TSH suppression therapy should incorporate the impact of side effects and set TSH targets to ensure the benefits of TSH suppression outweigh against the potential risks.
  • 摘要：目的 探讨PTCⅡ区淋巴结转移与甲状腺疾病背景、肿瘤大小、位置及区域淋巴结相关转移等的关系.方法 采用Access数据库软件行TC数据库建设,回顾性细化分析2013年8月至2014年3月四川省肿瘤医院头颈外科一病区收治的62例行颈部淋巴结清扫的PTC患者的临床资料,包括性别、年龄、甲状腺疾病背景、病灶数量、大小、位置、淋巴结转移数目等.结果 Ⅱ区淋巴结转移30例(其中Ⅱa区27例,Ⅱb区6例).没有任何甲状腺疾病背景的患者Ⅱ区转移(13/23),合并桥本氏甲状腺炎(9/17),合并结节性甲状腺肿(3/18),甲状腺功能亢进碘131治疗后(2/2);肿瘤直径＜10 mm(2/15),肿瘤大小10～40 mm(17/32),肿瘤直径＞40 mm (4/7).肿瘤位于上极(11/17),中份(12/23),下极(3/12).结论 Ⅱ区淋巴结转移在Prc中并不少见,目前的报道大多认同当Ⅲ区、Ⅳ区多发淋巴结转移或包膜外侵时,Ⅱ区阳性率较高,应当清扫.除传统危险分层外,Ⅱ区淋巴结转移特点与原发灶肿瘤位置及大小、甲状腺疾病背景等均有相关性,为了减少患者手术创伤、手术并发症,对每位患者予以个体化手术治疗方案,特别是肿瘤位于中上份,Ⅱ区淋巴结应予以重视.%Objective To investigate the correlation between level Ⅱ cervical lymph node metastasis (CLNM) and thyroid disease background,tumor size,location,and local lymph node metastasis in patients with papillary thyroid carcinoma (PTC).Methods A thyroid cancer database was established using Access database software.62 patients with PTC undergoing neck dissection in the 1st Department of Head and Neck surgery of Sichuan Cancer Hospital from Aug.2013 to Mar.2014 were retrospectively reviewed in terms of their sex,age,thyroid disease background,number of nodules,tumor size,location,and CLNM.Results 30 out of 62 patients had level Ⅱ cervical lymph node metastasis (Ⅱa:27 cases,Ⅱb:6 cases).13 out of 23 patients without history of other thyroid disease had level Ⅱ CLNM,9 out of 17 patients with Hashimoto's thyroiditis had level Ⅱ CLNM,3 out of 18 patients concomitant with nodular goiter had level Ⅱ CLNM and 2 patients concomitant with hyperthyroidism and having received radioactive iodine 131 treatments had level Ⅱ CLNM.Among patients with level Ⅱ CLNM,2 patients had tumors ＜10 mm,17 patients had tumors between 10 mm and 40 mm,and 4 patients had tumors ＞40 mm.Most of the tumors (11/17) with level Ⅱ CLNM were located in the upper polar of the thyroid,while the rest were located in the middle (12/23) and lower (3/12) region of thyroid.Conclusions Level Ⅱ CLNM is a common feature of thyroid carcinoma.It has been well accepted that level Ⅱ cervical lymph node should be dissected when extracapsular invasion or CLNM to level Ⅲ or Ⅳ occurs.In addition to traditional risk stratification,level Ⅰ CLNM is correlated with tumor size,location,and thyroid disease background.Therefore,close attention should be paid to level Ⅱ cervical lymph node when tumors are located in the upper polar of thyroid and individualized treatment should be chosen for each patient.
  • 摘要：目的 探讨PTC患者组织和血清中乙酰肝素酶(heparanase,Hpa)的表达与临床意义.方法 应用免疫组织化学法(SP)和酶联免疫法(ELISA)检测38例PTC及37例良性甲状腺结节患者组织及术前血清中Hpa蛋白的表达情况,同时检测30例正常人血清中Hpa蛋白的表达作为对照.结果 PTC组织中Hpa的表达高于良性甲状腺结节(P＜0.01),PTC组织中有周围淋巴结转移组Hpa的表达高于无周围淋巴结转移组(P＜0.05).良性甲状腺结节患者血清中Hpa含量与正常对照组比较,差异无统计学意义(P＞0.05),PTC患者血清Hpa含量高于良性甲状腺结节组及正常对照组(P＜0.01),有无淋巴结转移患者血清中Hpa含量,差异无统计学意义(P＞0.05).结论 组织及术前血清中Hpa检测对PTC诊断有一定价值,且组织中Hpa检测可用于判定PTC淋巴是否转移,而术前血清中Hpa检测尚不能用于判定PTC是否发生淋巴转移.%Objective To investigate the expression of heparanase (Hpa) in serum and tissue of patients with papillary thyroid carcinoma (PTC) and its clinical significance.Methods Immunohistochemical method (SP) and enzyme linked immunosorbent assay (ELISA) were used to detect the expression of Hpa protein in serum and tissues of 38 cases of PTC,37 cases of patients with benign thyroid nodules,and 30 normal controls.Results Expression of Hpa in PTC was higher than that of benign thyroid nodules (P＜0.01).Expression of Hpa in lymph node metastasis group was higher than that in group without lymph node metastasis (P＜0.05).Compared with the normal control group,the content of serum Hpa in patients with benign thyroid nodules had no significant difference (P＞0.05).Hpa content in serum of patients with PTC was higher than that of benign thyroid nodules group and the normal control group (P＜0.01).There was no statistically significant difference of the level of serum Hpa between groups with and without lymph node metastasis.Conclusions Detecting tissue and preoperative serum Hpa concentration is valuable for diagnosis of PTC.Hpa detection in tissues can be used to determine whether there was lymph node metastasis in PTC patients,while Hpa detection in preoperative serum can not judge whether there is lymph node metastasis.
  • 摘要：The zinc finger protein A20 exists in many kinds of ceils in the body and plays multiple roles in physiological and pathological processes such as regulation of immune response,inflammatory diseases and cancers by inhibiting cell apoptosis induced by tumor necrosis factor (TNF) and restricting NFKB signaling pathway.Recently,the role of A20 in generation and development of tumors draws wide attention,hence,we summarized recent research progress of the relation between A20 and cancer in this review.%锌指蛋白A20存在于体内多种细胞,通过抑制TNF等介导的细胞凋亡、阻断NFKB信号通路等作用,参与机体多种生理、病理过程,如免疫反应的调节、炎症性疾病和恶性疾病等.近年来,A20在肿瘤发生发展中的作用引起研究者的广泛关注,本文就A20在恶性肿瘤中的研究进展作一综述.
  • 摘要：甲状腺髓样癌(medullary thyroid carcinoma,MTC)是一种来源于分泌降钙素的甲状腺滤泡旁细胞(又称C细胞)的神经内分泌肿瘤,其发病、诊断和治疗都独具特点.Ki67是一种增殖细胞相关的核抗原,在肿瘤的发生、发展中起到一定作用,在多种恶性肿瘤尤其是神经内分泌肿瘤中具有重要的临床意义,在胃肠道神经内分泌肿瘤中已成为分级指标.本文拟对神经内分泌肿瘤之一的MTC及Ki67在MTC中表达及临床意义的研究进行综述.%Medullary thyroid carcinoma is a kind of neuroendocrine tumor that originates from calcitoninproducing parafollicular C-cells of the thyroid.Its incidence,diagnosis and treatment are unique.Ki67 is a nuclear antigen related to cell proliferation.It plays an important role in tumor occurrence and development,and it has important clinical significance in a variety of malignancies.Ki67 proliferation index has become classification index in neuroendocrine tumors of the gastrointestinal tract.In this paper,we review the study of medullary thyroid carcinoma and the expression of Ki67 in medullary thyroid carcinoma.
  • 摘要：目的 探讨颈淋巴结阴性(cN0)PTC中央区淋巴结转移的高危因素及预防性中央组淋巴结清扫治疗的临床价值和可行性.方法 系统回顾性分析大连医科大学附属第二医院2012年1月至2014年1月诊治的315例cN0 PTC患者的临床资料,探讨cN0PTC中央区淋巴结转移的高危因素,阐述行预防性中央区淋巴结清扫的临床意义.结果 ①肿瘤大小、被膜浸润、肿瘤数目3个指标对cN0PTC中央区淋巴结转移有影响,差异有统计学意义(P＜0.05),影响cN0 PTC中央区淋巴结转移的高危因素为被膜浸润及肿瘤多发(P＜0.05);②术后并发症总的发生率为3.17％(10/315),并发暂时性RLN麻痹发生率为0.63％(2/315),暂时性甲状旁腺功能减退发生率为2.54％(8/315),治疗后恢复正常;无永久性RLN及甲状旁腺损伤等永久性并发症发生;③随访时间6～30个月,2例失访,无患者发生肿瘤局部复发、远处转移及死亡.结论 cN0 PTC 中央区淋巴结转移的高危因素为被膜浸润及肿瘤多发;随访无复发、远处转移及死亡发生,故对以上患者行预防性中央组淋巴结清扫是有必要的.%Objective To investigate the risk factors of central lymph node metastasis and significance of prophylactic central lymph node dissection for clinical N0 (cN0) patients with papillary thyroid carcinoma (PTC).Methods The clinical data of 315 patients with cN0 PTC in Department of General surgery,the Second Affiliated Hospital of Dalian Medical University from Jan.2012 to Jan.2014 were analyzed retrospectively.Results (Iumor size,infiltration of thyroid capsule,and tumor number were associated with central lymph node metastasis in patients with cN0 PTC(P＜0.05),and the high risk factors of central lymph node metastasis were infiltration of thyroid capsule and multiple lesions (P＜0.05);()The overall complication rate was 3.17％ (10/315),the rate of transient recurrent laryngeal nerve paralysis was 0.63％ (2/315),and the rate of transient hypoparathyroidism was 2.54％ (8/315).All patients with complications recovered after treatment.No patient developed permanent recurrent laryngeal nerve paralysis or hypoparathyroidism;()The follow-up time was 6 to 30 months,and 2 cases were lost.No patient developed local tumor recurrence,distant metastasis,or death.Conclusions The high risk factors of central lymph node metastasis in patients with cN0 PTC were infiltration of thyroid capsule and multiple lesions.No patient developed local tumor recurrence,distant metastasis,or death.It is preferable and necessary to perform prophylactic central lymph node dissection in patients with cN0 PTC.
  • 摘要：目的 探讨单发PTC的CT联合临床特征对中央组淋巴结转移(central lymph node metastasis,CLNM)的预测价值.方法 回顾经手术和病理证实的366例单发PTC的CT征象及临床资料,采用单因素和多因素logistic回归分析瘤体位置、甲状腺边缘接触情况、钙化、平扫及增强后边界、肿瘤大小、年龄、性别与中央组淋巴结转移的关系.结果 366例PTC中,中央组淋巴结转移阳性和阴性分别为155例和211例.单因素和多因素logistic回归分析均表明甲状腺边缘接触、直径、年龄和性别与中央组淋巴结转移相关,其中甲状腺边缘接触、直径＞1.0 cm、年龄＜45岁和男性在中央组淋巴结转移中更常见(P＜0.05).瘤体位置、钙化、平扫边界、增强后边界与中央组淋巴结转移无关(P＞0.05).结论 甲状腺边缘接触、直径＞1.0 cm、年龄＜45岁和男性是CLNM阳性的独立风险因素.%Objective To investigate the value of CT signs in combination with clinical materials of papillary thyroid carcinoma (PTC) to predict the central lymph node metastasis (CLNM).Methods This article reviewed the CT signs and clinical materials of 366 patients with surgically and pathologically verified PTC.The single factor and multi-factor logistic regression analyses were performed on the relation of tumor position,thyroid marginal contact,calcification,plain scan border,border after enhancement,diameter,age and sex with CLNM.Results Among the 366 patients with PTC,the number of patients with positive CLNM and negative CLNM was 155 and 211 respectively.The single factor and multi-factor logistic regression analysis indicated that the thyroid marginal contact,diameter,age and sex were related with CLNM,and the more common patients diagnosed with CLNM had the following features:thyroid marginal contact,a diameter ＞1.0 cm,age ＜45 years and males (P＜ 0.05).Among the single risk factors,the tumor position,calcification,plain scan border and border after enhancement were unrelated with CLNM (P＞0.05).Conclusion The thyroid margin contact,diameter＞l.0 cm,age＜45 years and males are independent risk factors in diagnosis of positive CLNM.
  • 摘要：Objective To explore the significance of carbon nanoparticles in routine central lymph node dissection of papillary thyroid microcarcinoma (PTMC).Methods 272 cases of PTMC admitted from 2013 to 2015 were retrospectively analyzed and they were divided into two groups,the experimental group who were given carbon nanoparticles during surgery (136 cases) and the control group (136 cases) without carbon nanoparticles.The total number of central lymph nodes,number of transfer,and the black dye lymph node number and transfer number in the experimental group were recorded.The total number of lymph nodes,and number of transfer in the control group were recorded.The metastasis rate of the two groups were analyzed.The number of parathyroid mistakenly cut and hypocalcemia cases of the two groups were counted.Parathyroid function was observed by determination of Ca2+ and PTH in blood.The incidence of recurrent laryngeal nerve (RLN) injury of the two groups was compared.Results The total number of central lymph nodes was 1216 and the transfer number was 481 in the experimental group,higher than those of the control group.The positive lymph node rate of the two groups was 39.6％ and 25.9％ respectively,and the difference was statistically significant.The mumber of patients with central lymph node metastasis was 63 and 42 respectively for the experimental group and the control group,and the transfer rate was 46.3％ and 30.8％ respectively.The difference was statistically significant.The rate of parathyroid mistakenly cut was 2.6％(7/261) and 14.7％ (28/193) respectively for the experimental group and the control group,and the difference was statistically significant.The difference of Ca2+ and PTH value at 3h,6h,and 12h after surgery between the two group was statistically significant.No RLN injury occured.5 cases in the experimental and 8 cases in the control group had temporary RLN injury.The difference was not statistically significant.Conclusions The application of carbon nanoparticles in PTMC surgery can help to improve the thoroughness of central lymph node dissection and to protect parathyroid function.However,its benefits to protect the recurrent laryngeal is uncertain.%目的 探讨纳米碳混悬液在甲状腺微小乳头状癌(papillary thyroid microcarcinoma,PTMC)行常规中央区淋巴结清扫术中的应用及临床意义.方法 将山西省人民医院普外科甲状腺专业组2013年3月至2015年1月收治的PTMC患者272例,采用随机数字表法分为2组:实验组(136例),术中使用纳米碳混悬液;对照组(136例).记录实验组中央区淋巴结总数和转移数、黑染淋巴结数和转移数.记录对照组的淋巴结总数、转移数,分析2组的转移率.分别统计2组的甲状旁腺误切数、出现低钙血症的例数,通过测定血钙、甲状旁腺素来观察甲状旁腺的功能.观察2组RLN损伤的发生率.结果 实验组中央区淋巴结检出总数1216枚,转移数481枚,均高于对照组(943枚、245枚).2组的淋巴结阳性率分别为39.6％、25.9％,差异具有统计学意义.实验组和对照组中央区淋巴结转移的患者数和转移率分别为63例(46.3％)和42例(30.8％),差异具有统计学意义.实验组和对照组甲状旁腺误切率分别为2.6％ (7/261)和14.7％ (28/193),差异具有统计学意义.实验组和对照组术后3、6及12 h血钙和甲状旁腺素测定值之间差异均具有统计学意义.2组均无永久性RLN损伤,实验组暂时性RLN损伤的发生率为5例(3.68％),对照组暂时性RLN损伤的发生率为8例(5.89％),2组间差异无统计学意义.结论 纳米碳混悬液有助于提高PTMC术中中央区淋巴结清扫的彻底性,保护甲状旁腺的功能,但对RLN的保护意义不确定.
  • 摘要：目的 探讨自噬相关蛋白Beclin1、p62、Atg5在浆液性卵巢癌中的表达及临床意义.方法 选择2014年1月至2015年12月在浙江省宁波市鄞州人民医院中西医结合肿瘤科行手术切除并经病理确诊的浆液性卵巢癌标本50例为观察组,同期因子宫肌瘤需切除正常卵巢标本10例为对照组,应用免疫组化法检测自噬相关蛋白Beclin1、p62、Atg5蛋白表达水平结合卵巢癌临床参数分析.结果 浆液性卵巢癌组织中Beclin1、Atg5蛋白阳性表达率分别为38.0％、32.0％,均显著低于正常卵巢组织80.0％、70.0％;但浆液性卵巢癌组织中其p62蛋白阳性表达率72.0％,显著高于正常卵巢组织10.0％,差异有统计学意义(P＜0.05).Beclin1、Atg5的表达与浆液性卵巢癌临床分期、细胞分化程度之间均显著相关(P＜0.05),而p62蛋白的表达与临床分期、淋巴结转移相关(P＜0.05).结论 自噬相关蛋白Beclin1、p62、Atg5在浆液性卵巢癌中的异常表达,可致自噬功能减低和自噬体形成减少,可能在浆液性卵巢癌的发生、发展发挥重要作用.%Objective To investigate the expression of Beclin1,p62 and Atg5 in serous ovarian cancer and its clinical significance.Methods The expression of Beclin1,p62 and Atg5 was detected in 50 serous ovarian cancer tissues by immunohistochemical method,and the relationship between their expression levels and the clinical parameters of serous ovarian cancer patients were analyzed.Results The expression of Beclin1 and Atg5 in serous ovarian cancer tissue was significantly lower than that in normal ovarian tissue,but p62 was significantly higher than that in normal ovarian tissue,and the difference had statistically significance (P＜0.05).The expression of Beclin1 and Atg5 were correlated with degree of cell differentiation and clinical stage (P＜0.05),while the expression of p62 was associated with clinical stages and lymph node metastasis (P＜0.05).Conclusions The abnormal expression of Beclin1,p62,Atg5 in serous ovarian cancer,which can lead to reduced autophagy body formation and autophagy activity,may be involved in the occurrence and development of serous ovarian cancer.
  • 摘要：Long non-coding RNA(lncRNA) is non-protein coding transcripts longer than 200 nucleotides,which plays an important role in the development of the metabolic process.Thyroid cancer is the most common cancer of the endocrine system,and as reported,lncRNA is related to the occurrence and development of thyroid tumors.Therefore,this paper reports the latest domestic and foreign research progress about lncRNA in thyroid tumor,in order to provide new ideas for molecular diagnosis and treatment of thyroid cancer.%长链非编码RNA(long noncoding RNA,lncRNA)是一组长度大于200个核苷酸、缺少完整的开放阅读框、无蛋白质编码功能的RNA,在机体发育代谢过程中发挥重要作用.TC是内分泌系统最常见肿瘤,且有报道lncRNA与TC的发生发展相关.本文结合国内外最新报道,对lncRNA在TC中的研究进展做一综述,以期为TC的分子诊断和治疗提供新的思路.
  • 摘要：目的 探讨桥本氏病(hashimoto's thyroiditis,HT)患者血清TSH水平升高对甲状腺组织癌变的影响.方法 回顾性分析内蒙古医科大学附属医院甲状腺乳腺外科2009年1月至2013年12月收治的病理证实为HT的569例资料,根据是否合并PTC分为单纯HT组和HT合并PTC组.探讨年龄、性别、术前甲状腺功能(FT3、FT4、TSH、甲状腺过氧物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb))、多灶发生等相关因素.结果 569例病理证实为HT的患者中306例为单纯HT,263例为HT合并PTC.HT合并PTC患者平均年龄(45.52±10.58)岁＜单纯HT组(51.63±9.50)岁(P＜0.05).单纯HT患者血清TGAb、TPOAb明显高于HT合并PTC组(P＜0.05).其中HT合并PTC组,TSH升高(＞4.2mU/L)者31％(81/263),而单纯HT组,TSH升高者22.5％(69/306),差异有统计学意义(P＜0.05).HT合并PTC组TSH升高者,多灶癌发生32％(26/81),而TSH正常(0.2～4.2 mU/L)者,多灶癌发生29％(52/182),差异无统计学意义(P＞0.05).结论 术前血清TSH升高可能促进HT病患者甲状腺组织癌变,但对多灶癌发生无明显影响.%Objective To investigate the effect of high serum thyroid stimulating hormone (TSH) on malignant transformation of thyroid tissue in Hashimoto's thyroiditis (HT).Methods The data of 569 patients pathologically confirmed HT admitted from Jan.2009 to Dec.2013 were retrospectively analyzed.According to with or without papillary thyroid carcinoma (PTC),patients were divided into HT group and HT complicated with PTC group.Age,gender,preoperative TSH,free thyroxine,free tri-iodothyronine,thyroidperoxidaseantibody (TPOAb),antithyroglobulinanfibody (TGAb),and tumor multifocality were investigated.Results Among the 569 patients,306 patients had HT without PTC and 263 had HT with PTC.The avaerage age of patients complicated with PTC was (45.52±10.58) years,younger than that of patients without PTC (51.63+9.50) years (P＜0.05).In HT patients with or without PTC,31％ (81/263) and 22.5％ (69/306) of patients had high TSH levels,which was significantly different (P＜0.05).Among HT patients complicated with PTC,tumor multifocality was identified in 32％(26/81) of patients with high level of TSH and in 29％(52/182) of patients with normal level of TSH.The difference had no statistical significance (P＞0.05).Conclusion High preoperative TSH level may stimulate malignant transformation of thyroid tissue in HT patients.
  • 摘要：目的 探讨PTC右侧RLN后方Ⅵ b2区淋巴结清扫的临床意义.方法 回顾性收集福建医科大学附属协和医院甲状腺外科2013年2月至2014年3月111例PTC的临床资料,分析中央区淋巴结转移情况,并采用单因素及多因素分析方法分析PTC Ⅵ b区RLN后方Ⅵ b2区淋巴结转移与患者性别、年龄、肿瘤大小、包膜浸润等因素的相关性.结果 111例PTC中71例中央区淋巴结转移,转移率为63.96％;Ⅵ b区RLN后方Ⅵ b2区淋巴结总清扫数(2.720±2.037),转移率为27.03％ (30/111),均低于Ⅵ b1区(P＜0.05).单因素分析表明Ⅵ b2区淋巴结转移与患者的年龄、侧颈部淋巴结清扫及Ⅵb1区淋巴结转移有关(P＜0.05);Ⅵ b1区淋巴结转移是Ⅵ b区RLN后方Ⅵ b2区淋巴结转移的独立危险因素.结论 右侧PTC患者Ⅵ b区RLN后方Ⅵ b2区淋巴结转移率高,清扫有利手术的规范性及彻底性,能比较准确地反映淋巴结的转移情况,从而对肿瘤进行准确的分期,以指导术后治疗.%Objective To assess clinical significance of the right side lymph node dissection behind recurrent laryngeal nerve (RLN) in papillary thyroid carcinoma (PTC).Methods Clinical data of 111 cases of PTC adimitted in our hospital (Department of Vascular and Thyroid Surgery,the Union Hospital of Fujian Medical University) from Feb.2013 to Mar.2014 were retrospectively analyzed.Central lymph node metastasis was analyzed.Univariate and multivariate analysis were made to analyze relations between the right side lymph node (Ⅵ b2) metastasis behind RLN and gender,age,tumor size,capsule infiltration and so on.Results Among 111 cases of PTC,71 had central lymph node metastasis (63.96％).Total metastasis number of the right side lymph node behind recurrent laryngeal nerve (Ⅵ b2) was 2.720±2.037,and the transfer rate was 27.03％ (30/111) (P＜0.05),all lower than those of Ⅵ bl.The one-way ANOVA results showed that metastasis of the right side lymph node behind RLN (Ⅵ b2) was related with age,lateral neck dissection,and Ⅵ b1 lymph node metastasis (P＜0.05) while Ⅵ bl lymph node metastasis was the only independent risk factor for metastasis of the right side lymph node behind RLN(Ⅵ b2) in PTC.Conclusion For patients with right PTC,the metastasis rate of Ⅵ b2 is high,thus dissection of this area is favorable and can accurately reflect lymph node metastasis and further to guide tumor staging and postoperative treatment.

    中华内分泌外科杂志的期刊信息

    • 曾用名：内分泌外科杂志;内分泌外科
    • 创刊时间：2007
    • 地区：CN
    • 语言：中文
    • 热门主题：中华医学会
    • 学科分类：

    中华内分泌外科杂志的获奖情况

    中华内分泌外科杂志的收录情况

    • • 化学文摘（网络版）
    • • 中国科技核心期刊

    中华内分泌外科杂志的投稿信息

    • 投稿方式：在线投稿
    • 投稿须知：点击查看
    • 期刊官方网站：点击前往
    • 通讯地址：重庆市渝中区袁家岗友谊路1号
    • 邮编：400016
    • 联系电话：023-89012705
    • 邮箱：nfmwk2705@163.com
    • 期刊栏目：述评；论著；临床报道等
    免费订阅本刊

    客服邮箱：kefu@zhangqiaokeyan.com

    京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有 出版物经营许可证

    • 客服微信

    • 服务号