The Efficacy of Alcoholic Extract of Garlic on the Healing Process of Experimental Burn Wound in the Rabbit

摘要

>This investigation was evaluation of efficacy of alcoholic extract of garlic on the healing of burn wound in rabbit. In this study, 10 male white rabbits, weighing a mean of 2.200?±240 g were used. Based on Hoekstra standard model, a rectangular burn wounds (2x2.5 cm2) were created on back region of each rabbit. The wounds in experimental group were treated with alcoholic extract of garlic (5 mL) every day for 21 days. In the control group, the wounds were washed with normal saline (5 mL) at same frequency and time of day. The wounds were evaluated form clinical (rate of wound contraction) and microbiological (total count) aspects. The clinical findings of the present study were showed wound surfaces in the experiment group were significantly decreased in comparison to the control wounds (p<0.05). Microbiological evaluation was showed that total bacterial count of wound surfaces in garlic-treated group was lesser than this variable in the control wounds (p<0.05). With attention to these results, alcoholic extract of garlic can be considered as a topical agent for accelerating and enhancement burn wound healing in rabbit.