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Learning Cost-Effective and Interpretable Treatment Regimes

机译:学习具有成本效益和可解释的治疗方案

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Decision makers, such as doctors and judges, make crucial decisions such as recommending treatments to patients, and granting bails to defendants on a daily basis. Such decisions typically involve weighting the potential benefits of taking an action against the costs involved. In this work, we aim to automate this task of learning cost-effective, interpretable and actionable treatment regimes. We formulate this as a problem of learning a decision list – a sequence of if-then-else rules – which maps characteristics of subjects (eg., diagnostic test results of patients) to treatments. We propose a novel objective to construct a decision list which maximizes outcomes for the population, and minimizes overall costs. Since we do not observe the outcomes corresponding to counterfactual scenarios, we use techniques from causal inference literature to infer them. We model the problem of learning the decision list as a Markov Decision Process (MDP) and employ a variant of the Upper Confidence Bound for Trees (UCT) strategy which leverages customized checks for pruning the search space effectively. Experimental results on real world observational data capturing judicial bail decisions and treatment recommendations for asthma patients demonstrate the effectiveness of our approach.
机译:决策者,例如医生和法官,会做出至关重要的决定,例如向患者推荐治疗方法以及每天向被告提供保释金。此类决策通常涉及权衡采取行动的潜在利益与所涉及的成本。在这项工作中,我们旨在使这项任务自动化,以学习具有成本效益的,可解释的和可行的治疗方案。我们将其表述为学习决策列表(一系列if-then-else规则)的问题,该决策列表将受试者的特征(例如,患者的诊断测试结果)映射到治疗方法。我们提出了一个新颖的目标来构建决策列表,该决策列表可以最大程度地提高人口效益,并降低总体成本。由于我们没有观察到与反事实情景相对应的结果,因此我们使用因果推论文献中的技术进行推论。我们将学习决策列表的问题建模为马尔可夫决策过程(MDP),并采用树的上限可信度树(UCT)策略的一种变体,该变体利用自定义检查有效地修剪搜索空间。真实世界观察数据的实验结果捕获了对哮喘患者的司法保释决定和治疗建议,证明了我们方法的有效性。

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