THE INVOLVEMENT OF A FERROUS PROTEIN COMPLEX IN THE NATURAL ADRENALINE RECEPTOR

摘要

References(19) Cited-By(1) There have been many reports on the adrenaline receptor by many workers such as Dale (1), Ahlquist (2), Lands (3), Furchgott (4), and Ellis (5). In these reports various kinds of adrenaline receptors have been distinguished and given different names. However, such classification have been made only on the basis of differences in the response of the various organs to sympathomimetic and syrnpatholytic drugs with different chemical structures. Little is known about the nature of the receptor itself. A series of papers on the acetylcholine receptor by Nachmansohn's group (6, 7) and the papers by Woolley (8, 9) on the serotonin receptor are of interest in connection with the nature of the receptor itself. In this paper, the peculiar effect of ferrous ion on the vasoconstrictive action of adrenaline and on the binding of adrenaline with protein are described, and it is suggested that the adrenaline receptor may be a ferrous protein complex.