Orthogonal test design for optimization of the ultrasonic extraction of naringin from Citrus grandis tomentosa

摘要

Citrus grandistomentosa is a premature or maturescent dried pericarp ofC. grandistomentosa orC. grandis(L.)Osbeck, and it is one of the most important crude drugs in traditional Chinese medicine. In this article,C. grandistomentosa rich in naringin was used as an experimental material. This research, study the effects of ultrasonicextraction temperature, ratio of solvent to raw material, extraction time, and ultrasonic powerfor the extraction yield of naringin through a single-factor exploration. Then, through an orthogonal experiment (L9(3)4), it was investigated to get the best extraction conditions.The results showed that the effect of these factors on theextractionyield decreases in the order:extraction time& ultrasonic power& extraction temperature&ratio of solvent to raw material.The highest yield was obtained whentemperature, ratio of solvent to raw material, ultrasonic time and ultrasonic power were 40°C, 20:1, 50 min, and 280 W,respectively. the experiment was repeated three times with the selected condition, the averageextraction yield of naringinfrom theC. grandistomentosa was 82.11%. Compared with conventional extraction methods, ultrasonic extraction is time-saving, energy saving, and in the low temperature.