...
首页> 外文期刊>Drugs - Real World Outcomes >Patterns of High-Dose and Long-Term Proton Pump Inhibitor Use: A Cross-Sectional Study in Six South Australian Residential Aged Care Services
【24h】

Patterns of High-Dose and Long-Term Proton Pump Inhibitor Use: A Cross-Sectional Study in Six South Australian Residential Aged Care Services

机译:大剂量和长期使用质子泵抑制剂的模式:对六个南澳大利亚居民养老服务机构的横断面研究

获取原文
   

获取外文期刊封面封底 >>

       

摘要

AimWhile proton pump inhibitors (PPIs) are generally considered safe and well tolerated, frail older people who take PPIs long term may be susceptible to adverse events. This study characterized PPI use and determined factors associated with high-dose use among older adults in residential aged care services (RACSs). MethodsA cross-sectional study of 383 residents of six South Australian RACSs within the same organization was conducted. Clinical, diagnostic, and medication data were collected by study nurses. The proportions of residents who took a PPI for??8?weeks and without documented indications were calculated. Factors associated with high-dose PPI use compared to standard/low doses were identified using age- and sex-adjusted logistic regression models. Results196 (51%) residents received a PPI, with 45 (23%) prescribed a high dose. Overall, 173 (88%) PPI users had documented clinical indications or received medications that can increase bleeding risk. Three-quarters of PPI users with gastroesophageal reflux disease or dyspepsia had received a PPI for??8?weeks. High-dose PPI use was associated with increasing medication regimen complexity [odds ratio (OR) 1.02; 95% confidence interval (CI) 1.01–1.04 per one-point increase in Medication Regimen Complexity Index score] and a greater number of medications prescribed for regular use (OR 1.11; 95% CI 1.01–1.21 per additional medication). ConclusionsHalf of all residents received a PPI, of whom the majority had documented clinical indications or received medications that may increase bleeding risk. There remains an opportunity to review the continuing need for treatment and consider “step-down” approaches for high-dose PPI users.
机译:目的虽然质子泵抑制剂(PPI)通常被认为是安全且耐受性良好的,但长期服用PPI的体弱的老年人可能容易发生不良事件。这项研究表征了PPI的使用,并确定了居民老年护理服务(RACS)中老年人大剂量使用的相关因素。方法对同一组织内的六个南澳大利亚RACS的383名居民进行了横断面研究。临床,诊断和用药数据由研究护士收集。计算了服用PPI≥8周且没有书面证据的居民比例。使用年龄和性别调整后的逻辑回归模型,确定了与标准剂量/低剂量相比高剂量PPI使用相关的因素。结果196(51%)位居民接受了PPI,其中45位(23%)接受了大剂量处方。总体而言,有173名(88%)PPI用户记录了临床指征或接受了会增加出血风险的药物。四分之三的患有胃食管反流疾病或消化不良的PPI使用者接受PPI的时间≥8周。大剂量PPI的使用与药物治疗方案复杂性的增加相关[比值比(OR)1.02;药物治疗复杂性指数每提高1分,可信度区间(CI)为1.01–1.04,95%置信区间],并开出更多常规药物处方(OR 1.11;每增加一种药物,CI为95%CI 1.01–1.21)。结论所有居民中有一半接受了PPI,其中大多数人已证明其临床适应症或接受了可能增加出血风险的药物。仍有机会回顾对治疗的持续需求,并为大剂量PPI使用者考虑“逐步降低”方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号