首页> 外文OA文献 >Patterns of High-Dose and Long-Term Proton Pump Inhibitor Use: A Cross-Sectional Study in Six South Australian Residential Aged Care Services
【2h】

Patterns of High-Dose and Long-Term Proton Pump Inhibitor Use: A Cross-Sectional Study in Six South Australian Residential Aged Care Services

机译:高剂量和长期质子泵抑制剂的模式使用:六南澳大利亚住宅老年护理服务的横截面研究

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Abstract Aim While proton pump inhibitors (PPIs) are generally considered safe and well tolerated, frail older people who take PPIs long term may be susceptible to adverse events. This study characterized PPI use and determined factors associated with high-dose use among older adults in residential aged care services (RACSs). Methods A cross-sectional study of 383 residents of six South Australian RACSs within the same organization was conducted. Clinical, diagnostic, and medication data were collected by study nurses. The proportions of residents who took a PPI for > 8 weeks and without documented indications were calculated. Factors associated with high-dose PPI use compared to standard/low doses were identified using age- and sex-adjusted logistic regression models. Results 196 (51%) residents received a PPI, with 45 (23%) prescribed a high dose. Overall, 173 (88%) PPI users had documented clinical indications or received medications that can increase bleeding risk. Three-quarters of PPI users with gastroesophageal reflux disease or dyspepsia had received a PPI for > 8 weeks. High-dose PPI use was associated with increasing medication regimen complexity [odds ratio (OR) 1.02; 95% confidence interval (CI) 1.01–1.04 per one-point increase in Medication Regimen Complexity Index score] and a greater number of medications prescribed for regular use (OR 1.11; 95% CI 1.01–1.21 per additional medication). Conclusions Half of all residents received a PPI, of whom the majority had documented clinical indications or received medications that may increase bleeding risk. There remains an opportunity to review the continuing need for treatment and consider “step-down” approaches for high-dose PPI users.
机译:摘要瞄准而质子泵抑制剂(PPI)通常被认为是安全且耐受性良好的,占用PPI长期服用PPI的人可能会对不良事件感染。本研究表征了住宅老年护理服务(RACS)的老年人高剂量使用相关的PPI使用和确定的因素。方法进行同一组织内六南澳大利亚Racs的383名居民的横截面研究。通过研究护士收集临床,诊断和药物数据。计算了居民的比例> 8周,没有记录的指示。使用年龄和性别调整的逻辑回归模型鉴定与标准/低剂量相比的高剂量PPI使用相关的因素。结果196(51%)居民收到PPI,45(23%)规定了高剂量。总体而言,173名(88%)PPI用户已记录临床适应症或接受可能提高出血风险的药物。具有胃食管反流疾病或消化不良的四分之三的PPI用户接受了PPI> 8周。高剂量PPI使用与增加的药物方案复杂性相关有关[差距(或)1.02;每单点置信区间(CI)置信区间(CI)1.01-1.04药物方案复杂性指数评分的增加]和规定的常规用药数量(或1.11;每增加药物95%CI 1.01-1.21)。结论所有居民的一半接受了PPI,其中大多数人记录了临床适应症或接受可能提高出血风险的药物。仍有机会审查持续需要治疗,并考虑“降压”的高剂量PPI用户方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号