Asialoglycoprotein receptor targeted delivery of doxorubicin nanoparticles for hepatocellular carcinoma

Sandhya Pranatharthiharan; Mitesh D. Patel; Vinod C. Malshe; Vaishali Pujari; Ajit Gorakshakar; Manisha Madkaikar; Kanjaksha Ghosh; Padma V. Devarajan; show all

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Asialoglycoprotein receptor targeted delivery of doxorubicin nanoparticles for hepatocellular carcinoma

机译：去唾液酸糖蛋白受体靶向递送阿霉素纳米颗粒治疗肝细胞癌

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Abstract We report asialoglycoprotein receptor (ASGPR)-targeted doxorubicin hydrochloride (Dox) nanoparticles (NPs) for hepatocellular carcinoma (HCC). Polyethylene sebacate (PES)-Gantrez? AN 119 Dox NPs of average size 220?nm with PDI?p?

机译：摘要我们报道了以去唾液酸糖蛋白受体（ASGPR）为靶标的盐酸阿霉素（Dox）纳米颗粒（NPs）用于肝细胞癌（HCC）。聚乙烯癸二酸酯（PES）-Gantrez？ AN 119 Dox NP的平均大小为220？nm，PDI？p？<？0.05），有丝分裂指数为1.135（第46天），且肿瘤治疗/肿瘤控制（T / C）值为 0.42，表明其具有优越的疗效Pul NP。此外，NP组的体重增加，且无组织病理学改变表明它们被小鼠很好地耐受。 Pul Dox NPs具有较高的功效和更高的安全性，可作为改善肝癌治疗的有前途的纳米载体。

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《Drug delivery.》 |2017年第1期|共10页
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Sandhya Pranatharthiharan; Mitesh D. Patel; Vinod C. Malshe; Vaishali Pujari; Ajit Gorakshakar; Manisha Madkaikar; Kanjaksha Ghosh; Padma V. Devarajan; show all;
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1. Asialoglycoprotein receptor-magnetic dual targeting nanoparticles for delivery of RASSF1A to hepatocellular carcinoma [J] . Wan-Jiang Xue, Ying Feng, Fei Wang, Scientific reports. . 2016,第1期

机译：去唾液酸糖蛋白受体-磁性双重靶向纳米颗粒用于将RASSF1A递送至肝细胞癌
2. Galactose-modified selenium nanoparticles for targeted delivery of doxorubicin to hepatocellular carcinoma [J] . Yu Xia, Jiayu Zhong, Mingqi Zhao, Drug delivery. . 2019,第1期

机译：半乳糖修饰的硒纳米颗粒用于将阿霉素靶向递送至肝细胞癌
3. Targeted and synergistic therapy for hepatocellular carcinoma: monosaccharide modified lipid nanoparticles for the co-delivery of doxorubicin and sorafenib [J] . Wendu Duan, Yan Liu Drug Design, Development and Therapy . 2018,第InaProgress期

机译：肝细胞癌的靶向和协同治疗：阿糖修饰的脂质纳米颗粒用于阿霉素和索拉非尼的共同给药
4. Targeted Doxorubicin Delivery to Hepatocellular Carcinoma by Galactosylated Nanogel [C] . Juan Wu, Tian-Meng Sun, Meng-Hua Xiong, Annual meeting exposition of the Controlled Release Society . 2011

机译：半乳糖基化纳米凝胶靶向将阿霉素递送至肝癌
5. Epidermal Growth Factor Receptor mediated cellular and subcellular targeted delivery of Iron oxide core-Titanium dioxide shell nanoparticles. [D] . Yuan, Ye. 2014

机译：表皮生长因子受体介导的氧化铁核-二氧化钛壳纳米粒子的细胞和亚细胞靶向递送。
6. Asialoglycoprotein receptor targeted delivery of doxorubicin nanoparticles for hepatocellular carcinoma [O] . Sandhya Pranatharthiharan, Mitesh D. Patel, Vinod C. Malshe, 2017

机译：Asialoglycoprotein受体靶向递送多柔比星纳米粒子用于肝细胞癌
7. Development of Asialoglycoprotein Receptor-Targeted Nanoparticles for Selective Delivery of Gemcitabine to Hepatocellular Carcinoma [O] . Anroop B. Nair, Jigar Shah, Bandar E. Al-Dhubiab, 2019

机译：亚喹甲蛋白受体靶向纳米粒子的开发，用于选择性缩小蛋白酶递送至肝细胞癌

Asialoglycoprotein receptor targeted delivery of doxorubicin nanoparticles for hepatocellular carcinoma

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