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Hazardous Substances, CERCLA, and Nanoparticles – Can the Three be Reconciled?

机译:有害物质,CERCLA和纳米颗粒–三种可以调和吗?

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Toxicology research in the nanotechnology area has focused primarily on human inhalation, ingestion or dermal exposure. Less research has been published on the impact to ecological systems resulting from a release of nanomaterials. Environmental laws such as CERCLA (“Superfund”) address the release of “hazardous substances” by obligating the party releasing the substance to (a) report the release and (b) investigate the nature and extent of the release and to then remediate it to some objective cleanup standard. Applying this regime to the release of nanomaterials, however, is complicated. First, is the nanomaterial a hazardous waste, toxic substance, or hazardous substance as defined under the environmental laws? A compound that may be defined as hazardous or toxic could have properties at the nano level that are distinctly non-hazardous. Second, what constitutes a release of a nanoparticle that would require reporting under applicable environmental laws? Typically, release reporting is based upon the weight of the hazardous substance that is released, but for nanomaterials a weight threshold might be meaningless. Third, how do you sample nanoparticles in the field and analyze them using existing instrumentation? There are few approved tests for nanomaterials. Fourth, how do you determine an objective risk-based cleanup standard for the thousands of possible nanomaterials?.
机译:纳米技术领域的毒理学研究主要集中于人体吸入,食入或皮肤接触。关于纳米材料释放对生态系统的影响的研究较少。 CERCLA(“超级基金”)之类的环境法律规定了释放该物质的当事方有义务(a)报告该释放并(b)调查该释放的性质和程度,然后对其进行补救以解决“有害物质”的释放问题。一些客观的清理标准。然而,将这种机制应用于纳米材料的释放是复杂的。首先,纳米材料是环境法规中定义的有害废物,有毒物质还是有害物质?可以定义为危险或有毒的化合物可能在纳米级具有明显无害的特性。其次,什么构成纳米颗粒的释放,需要根据适用的环境法进行报告?通常,释放报告基于释放的有害物质的重量,但是对于纳米材料,重量阈值可能没有意义。第三,您如何在现场采样纳米颗粒并使用现有仪器进行分析?很少有经过批准的纳米材料测试。第四,如何确定成千上万种可能的纳米材料的基于风险的客观净化标准?

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  • 来源
    《Dose-response》 |2012年第3期|共页
  • 作者

    John Bashaw;

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  • 中图分类 药学;
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  • 入库时间 2022-08-18 15:49:41

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