Spectrophotometric determination of gold(III) using alfuzosin hydrochloride (R,S)-N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl) methylamino] propyl] tetrahydro-2-furancarboxamide hydrochloride. reagent

摘要

A Alfuzosin hydrochloride (AFZ) is chemically (R,S)-N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl) methylamino] propyl] tetrahydro-2-furancarboxamide hydrochloride. The empirical formula and molecular weight of alfuzosin hydrochloride are C19H27N5O4HCl and 425.9 respectively , was employed for the sensitive spectrophotometric determination of gold(III). The gold(III) ion forms a red-coloured complex with AFZ in an aqueous solution at pH 4.0. The gold complex shows the absorption maximum at 540 nm, and Beer,s law obeyed in the range of 4.92-78.76 μg/ml. The molar absorptivity and sandell, s sensitivity were found to be 1.92 x 103 mol-1 cm-1 and 0.0010 μg/cm2 respectively. The complex shows 1:1 [Au(III) : AFZ] stochiometry with a stability constant of 4.31 x 104. The interference effect of various diverse ions has been studied. In addition to zero- order, first derivative spectrophotometric methods was also developed for the determination of gold(III) in trace amount which was more sensitive than the zero-order method. The developed method has been used for the determination of gold(III) in various kinds of alloys. The results was in excellent agreement with certified values. ____________________________________________________________________________________________.