Plasma Gelsolin Level as a Predictive Factor for Ischemic Stroke Outcome

摘要

Background: Several biomarkers have been studied in ischemic stroke. Plasma gelsolin is a recent inflammatory stroke biomarker. Objective: The aim of this study was to determine whether plasma gelsolin level was altered in ischemic stroke patients and its ability to predict stroke outcome in these patients. Methods: This study was conducted on 50 patients with first-ever ischemic stroke and 30 healthy volunteers. Clinical and laboratory assessments were done to the patients and controls. After 3 months we divided our surviving patients into 2 groups according to modified Rankin Scale; group 1 included patients with good prognosis and group 2 included patients with bad prognosis and we compared between the 2 groups clinically, radiologically and as regarding baseline plasma gelsolin level. Results: We found that plasma gelsolin level was decreased significantly in the patients than controls. When we compared between good and bad prognosis groups we found that plasma gelsolin level was decreased significantly in the bad prognosis group and when we study the correlation of plasma gelsolin with other parameters we found that plasma gelsolin level was correlated significantly with National Institute of Health Stroke Scale and modified Rankin Scale and Barthel Index. Conclusion: This study suggested that plasma gelsolin level is a good marker for the severity of stroke and stroke outcome. [Egypt J Neurol Psychiat Neurosurg.  2013; 50(4): 419-424] Key words: Ischemic stroke, Plasma gelsolin level, Stroke outcome.