Q-Absorbance and Multicomponent UV - Spectrophotometric Methods for Simultaneous Estimation of Rosuvastatin calcium and Fenofibrate in Pharmaceutical Formulation

摘要

Two simple UV-Spectrophotometric methods have been developed for simultaneous determination of Rosuvastatin calcium and Fenofibrate in pharmaceutical formulation. Methanol AR grade was used as solvent. In Method-I (Qabsorbance absorbance ratio) involves formation of Q-absorbance equation at two wavelengths i.e. 255.99 nm (isoabsorptive point) and 286 nm (λ max of Fenofibrate). While, in Method-II (Multicomponent Mode of Analysis) involves the measurement of absorbance at two wavelengths i.e. 243 nm, λ max of Rosuvastatin calcium and 286 nm, λ max of Fenofibrate. In both methods, Rosuvastatin calcium and Fenofibrate followed same linearity range at the concentration of 03 - 18 μg/ml at their respective λ max. Both these methods were found to be accurate, precise and rugged as indicated by low values of % RSD. Both these methods were also found to be rapid and economical can successfully be applied for the routine analysis of bulk and combined tablet dosage form.