Formulation and Evaluation of sub dermal Implants containing NSAID

摘要

The concept of implantable therapeutic system for the long term therapy is a newer and developing area in drug research programmes Subcutaneous route is selected for the sustained and prolong release of drugs, non steroidal anti-inflammatory drugs like, Piroxicam are model drugs used subcutaneous route is selected because it contains less no. of nerve network which should be helpful for implantation this route contains max. rate of drug absorption with less no. of side effects .It avoids first pass effect metabolisms,& other type of drug loss through different organs of the body. In the present piece of investigation an attempt has been made to design and develop some biodegradable sub dermal implants. Piroxicam a non steroidal anti inflammatory drugs has been selected to prepare rod shaped implants with the help of Gelatin and Chitosan its cross linking nature with glutaraldehyde. The implants were evaluated for drug content uniformity, thickness, weight variation, in vitro studies and stability studies at ambient temperature for three months implants were found to erode slowly with diffusion mechanism.