HIV Disease and Renal Function

摘要

Catherine Leport and colleagues from the?APROCO-COPILOTE cohort published long-term results of renal function in over 1100 patients whostarted protease inhibitor (PI) based combinations between?1997 and 1999 in 47 French HIV centres. [1]Changes in eGFR in this cohort, estimated by MDRD ignoring adjustment for race, increased by +0.72 mL/min/1.73m2/month (95%CI 0.40?1.03) from treatment?initiation to month 16 and then remained stable +0.01/month (95% CI, -0.08 to 0.10) for up to 7 years. The proportion ofpatients with a GFR of <60 or?60?90 were stable over time at approximately 5% and 39%.