Bone marrow transplant donor recruitment strategies to maximize, optimize, and equalize recipient chances of an acceptable match

摘要

Dear Editor,The number of named alleles of the human leukocyte antigen (HLA) genes, HLA-A, HLA-B and DRB1 are 3399, 4242 and 1883,1, 2 respectively. Owing to analyses of the frequencies and distributions of these alleles worldwide, 246 HLA-A alleles, 367 HLA-B alleles and 226 HLA-DRB1 alleles are now common or well documented.3 As the first step in finding a bone marrow match for a new patient, an algorithm scans the entire registry every day and displays possible donors that match the recipient's genotype. Then, new and complementary HLA typings are requested for loci DQB1 and C and allelic level for Class II, and if the donor is in good health, a confirmatory high-resolution HLA test is performed.