C-MYC is related to GATA3 expression and associated with poor prognosis in nodal peripheral T-cell lymphomas

摘要

Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin lymphomas (NHLs), characterized by aggressive clinical behavior. Nodal PTCL (n-PTCL) includes four disorders. angioimmunoblastic T-cell lymphoma (AITL), peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) and anaplastic large cell lymphoma (ALCL) (ALK-positive and ALK-negative forms). While AITL and ALCL both have their own particular morphological and phenotypic features, n-PTCL-NOS comprises a variety of peripheral T-cell lymphomas. Recently, gene expression studies have identified three subgroups of PTCL-NOS that have prognostic implications. One is characterized by the overexpression of TBX21 and a better outcome, and the other two, which have a worse prognosis, have either cytotoxic markers or GATA3 overexpression.~(~(1))Iqbal et al .~(~(1)) found the GATA3-positive subgroup of tumors to be enriched in MYC and proliferation gene signatures, amongst others. MYC is one of the most frequently dysregulated oncogenes in cancer and is critical to the development of mature PTCLs.~(~(2)).