Metabolik Sendromlu Hastalarda TIMI Kare Say?s?n?n Prognostik De?eri

摘要

Background: The aim of our study was to determine the coronary angiographic distribution and frequency of atherosclerotic lesions in the coronary arteries in patients with stable angina and metabolic syndrome (MS) as well as to assess the association of these lesions with TIMI frame count and combinations of MS criteria. Methods: Two hundred sixty-one patients aged 61.8±1.4 years were included in the study. All subjects were divided into three large groups: group 1 - patients with significant coronary artery stenosis and with MS (n=148), group 2 - patients with significant coronary artery stenosis and without MS (n=75), and group 3 - patients without significant coronary artery stenosis and without MS (n=38). At the same time, the patients in group 1 were again divided into 3 subgroups based on the number of MS criteria. Arterial blood pressure (BP), waist circumference (WC), and levels of fasting glucose (FG), triglycerides (TG) and high-density lipoproteins (HDL) were measured in all patients. All subjects underwent coronary angiography and TIMI frame count was calculated. Results: According to the results in patients with stable angina with 5 criteria of MS, the TIMI frame count was significantly greater than in patients with stable angina with 3 and 4 criteria of MS. While in the group of patients with stable angina with 3 criteria of MS, the most frequent combination found was BP +WC + FG (28.3±6.2%), in patients with stable angina with 4 MS criteria, it was BP + WC + FG + HDL combination (48.0±7.1%). Conclusions: The TIMI frame count method is simple, inexpensive and broadly applicable and plays role in the understanding of the physiology and pathophysiology of coronary artery blood flow in patients with stable angina and MS. For this reason, the calculation of TIMI frame count in patients with stable angina and MS has an important place in selecting the treatment options and determining the prognosis of the disease. Turk Jem 2011; 15: 1-7 ?zet Ama? : Yapm?? oldu?umuz ?al??man?n amac? metabolik sendromu (MS) olan stabil anginal? hastalarda aterosklerotik lezyonlar?n koroner anjiyografik da??l?m? ve s?kl???n?n belirlenmesi ve ayn? zamanda bu lezyonlarla TIMI kare say?s? ve MS kriter kombinasyonlar? aras?nda ili?kinin de?erlendirilmesidir. Materyel ve Metod: ?al??maya ortalama ya?? 61.8±1.4 olan 261 hasta al?nd?.Tüm hastalar 3 büyük gruba ayr?ld?. Grup 1`e MS ve koroner arterlerde anlaml? darl?k olan 148 hasta, grup 2`e koroner arterlerde anlaml? darl?k olan ve MS olmayan 75 hasta, grup 3`e MS ve koroner arterlerde anlaml? darl?k olmayan 38 hasta al?nd?. Ayn? zamanda grup 1`de olan hastalar MS kriter say?s?na g?re 3 alt gruba ayr?ld?.Hastalarda arteryel kan bas?nc? (KB), bel ?evresi (B?), a?l?k kan ?ekeri (AK?), trigliserid (TG) ve yüksek yo?unluklu kolesterol (HDL) de?erleri ?l?üldü. Hastalarda selektif koroner anj?yografi yap?larak TIMI kare say?s? hesapland?. Bulgular :MS 5 kriteri bulunan stabil anginal? hastalar?n TIMI kare say?s? de?erleri, MS 3 ve 4 kriteri bulunan stabil anginal? hastalar?n TIMI kare say?s? degerlerine g?re anlaml? olarak daha fazla bulundu. MS 3 kriteri olan stabil anginal? hastalarda KB+B?+AK? (28,3±6,2%) kombinasyonu daha s?k g?rüldü. MS 4 kriteri olan stabil anginal? hastalarda ise en s?k KB+B?+AK?+HDL (48,0±7,1%) kombinasyonu g?rüldü. Sonu? :TIMI kare say?s? basit, ucuz ve geni? uy?ulanan metot olarak, MS ve stabil anginas? olan hastalarda koroner kan ak?m?n?n fizyolojisi ve patofizyolojisi ile ilgili ?nemli bilgiler verir. MS`i olan stabil anginal? hastalarda TIMI kare say?s?n?n hesaplanmas? hastal???n prognozunun tayininde ve tedavi se?iminde ?nemli rolü olacakt?r.Türk Jem 2011; 15: 1-7