Protective Effects of Sporoderm-Broken Spores of Ganderma lucidum on Growth Performance, Antioxidant Capacity and Immune Function of Broiler Chickens Exposed to Low Level of Aflatoxin B 1

摘要

This study was conducted to investigate the toxic effects of aflatoxin B 1 (AFB 1 ) and evaluate the effects of sporoderm-broken spores of Ganoderma lucidum (SSGL) in relieving aflatoxicosis in broilers. A total of 300 one-day-old male Arbor Acre broiler chickens were randomly divided into four dietary treatments; the treatment diets were: Control (a basal diet containing normal peanut meal); AFB 1 (the basal diet containing AFB 1 -contaminated peanut meal); SSGL (basal diet with 200 mg/kg of SSGL); AFB 1 +SSGL (supplementation of 200 mg/kg of SSGL in AFB 1 diet). The contents of AFB 1 in AFB 1 and AFB 1 +SSGL diets were 25.0 μg/kg in the starter period and 22.5 μg/kg in the finisher period. The results showed that diet contaminated with a low level of AFB 1 significantly decreased ( p < 0.05) the average daily feed intake and average daily gain during the entire experiment and reduced ( p < 0.05) serum contents of total protein IgA and IgG. Furthermore, a dietary low level of AFB 1 not only increased ( p < 0.05) levels of hydrogen peroxide and lipid peroxidation, but also decreased ( p < 0.05) total antioxidant capability, catalase, glutathione peroxidase, and hydroxyl radical scavenger activity in the liver and spleen of broilers. Moreover, the addition of SSGL to AFB 1 -contaminated diet counteracted these negative effects, indicating that SSGL has a protective effect against aflatoxicosis.