Correlation of Metabolic Pathways with the Primary Structure in Acetylated Proteins

摘要

Signaling pathways are the major component in cellular networks, but most studies done recently on signalingpathways were either aimed to enhance various molecular predictions using pathways as contexts or focused to predictpathways indirectly. The former assumed that the pathways for the biomolecules (genes or proteins) used in the modellingwere known. Although the latter was well suiting the biosciences researches at the systems level, the indirect predictionswould more or less rely on the prediction accuracy of other systems. So far no work whatsoever has been done for studyingthe direct correlation between signaling pathways and protein primary structures although acetylated proteins are oneof the main players in metabolic signaling pathways. In order to investigate their correlation, the sequences of 76 experimentallyverified acetylated proteins were downloaded from NCBI. They cover three major metabolic pathways, i.e., biosynthesis,degradation, and metabolism. Without any a prior knowledge about how these three metabolic pathways arecorrelated with the primary structures of acetylated proteins, we proposed some classification models between the pathways.It has been found through computer simulations that the signaling pathways are indeed correlated with the primarystructures in acetylated proteins, further demonstrating the well-known biological law that sequence determines structureand structure determines function.