PROPHYLAXIS OF POSTOPERATIVE NAUSEA AND VOMITING LAPAROSCOPIC PROCEDURES WITH 5-HT3 RECEPTOR ANTAGONISTS, A RANDOMIZED CONTROLLED TRIAL.

摘要

In this study we aim to study the efficacy of Ramosetron and Palonosetronin preventing post-operative nausea and vomiting in high risk patients. Study Design: Arandomized controlled trial. Setting: A Large Tertiary Care Centre in Karachi. Period: 9 monthsfrom January 2017 to September 2017. Materials and Methods: N=81 participants tookpart in the study. The patient population was divided into three groups.. Patients belongingto group A received Palonosetron 0.075mg mixed with normal saline in a mixture of 3ml, priorto induction, and received 3ml of normal saline half an hour prior to the end of the procedure.Patients in group B received 3ml of normal saline prior to induction and a mixture of 0.3mg ofRamosetron mixed with normal saline as 3ml half an hour before end of procedure. In groupC patients received normal saline 3ml both before induction and half an hour prior to end ofsurgery. Results: The patient demographics were similar in all the groups and no significantdifference was found. The incidence of post-operative nausea and vomiting during 2 hours postoperatively was 41.97%, the incidence of nausea at 2 hours was in group A= 33.33%, in groupB= 29.62%, in group C= 62.96% respectively, having a p value of 0.014 refer to table 2. After48 hours of surgery the overall incidence of vomiting in the groups was not significant havinga p value of 0.428 and an incidence of 6.172%. Conclusion: Palonosetron and Ramosetronare equally effective in prevention of post-operative nausea and vomiting in high risk patientsundergoing laparoscopic gynecological procedures.