Macular Hole Formation After Intravitreal Ranibizumab Injection in WetAge-Related Macular Degeneration

摘要

Ranibizumab is a monoclonal antibody fragment that inhibits angiogenesis by inhibiting vascular endothelialgrowth factor A, used as a treatment for patients with wet aged-related macular degeneration (ARMD). Adverse effectsfrom intravitreal Ranibizumab injections are well recognised. Macular hole formation following Ranibizumab injection isa complication that has been recently reported in few case reports. We present a larger case series of five patients, whodeveloped full thickness macular holes (FTMH) after intravitreal Ranibizumab injections for treatment of wet ARMD thatwe were aware of between 2009 and 2013.