Is there is Need for Ubiquinone (CoQ10) Supplementation in Statin-Associated Myopathy?

摘要

Statins are currently the most effective drugs in reducing low-density lipoprotein cholesterol (LDL-C). Withtheir mechanism of action, by inhibiting 3-hydroxy-3 methylglutharyl coenzyme A reductase, statins decrease cholesterolproduction. The same biosynthetic pathway is shared by ubiquinone or coenzyme Q10. Statins block production ofdekaprenyl-4-benzoate, a precursor of coenzyme Q10 (CoQ10), which is an essential component in mitochondrialtransport system. Ubiquinone deficiency may affect oxidative phosphorylation and adenosine triphosphate production,which can subsequently result in impairing of muscle energy metabolism and contribute to development of myopathy.Statin therapy also decreases antioxidant status in the body, resulting in to increase in free radical damage to cells invarious parts of body; liver, nerves, muscles. Statins can decrease natural antioxidant protection present in our body andpredispose toxicity.Statin-associated myopathy is the most common side effect of statin treatment often lead to statin dose reduction, or therapy cessation, which can negatively affect cardiovascular risk management. The spectrum of statin-related myopathy ranges from common but clinically benign myalgia to rare but life-threatening rhabdomyolysis. Observational studies suggest that myalgia can occur in up to 10% of persons prescribed statins, whereas rhabdomyolysis continues to be rare. Statins lower circulating levels of CoQ10 up to 54%, whereas several studies did not confirmed a lowering of CoQ10 levels in muscles during statin therapy and the evidence was given also on low dose of statin therapy, which did not appear to reduce intramuscular levels of CoQ10 in symptomatic patients with statin myopathy. The conflicting results have been published on the impaired mitochondrial function, which was found during the analysis of the myocyte cells in patients treated with statins. The supplementation of CoQ10 results in increasing of serum CoQ10, but it is not clear if it relieves myopatic symptoms in statin treated patients. Yet available intervention studies reported contrasting results and just two of them proved benefit of CoQ10 supplementation. Hence coenzyme Q10 supplementation is not currently recommended for routine use in the prophylaxis of statin toxicity.