THE ROLE OF ERYTHROPOIETIN IN APLASTIC ANEMIASOME ASPECT FOR ETIOLOGY AND TREATMENT OF APLASTIC ANEMIA

摘要

1) The plasma EP levels of patients with idiopathic aplastic anemia and other cases were measured simultaneously by the methods of Fried, Krantz and Matoth. EP titer in aplastic anemia was found to be higher when serum (plasma) was tested by the method of Fried (in vivo assay) and lower when tested by the methods of Matoth and Krantz (in vitro assay), although results were equal by any of the three method in all other cases.2) Causes of the different EP level in cases of aplastic anemia were dis-cussed.8) The bone marrow of patients with idiopathic aplastic anemia when tested in vitro revealed an increased incorporation rate in response to EP rich plasma as observed in the bone marrow of the normal individual.4) Treatment with EP rich plasma showed a remarkable effect on almost all patients with idiopathic aplastic anemia which did not respond to the normal plasma given as the control.5) Discussions whether or not EP if purified, will be a useful agent in the treatment of idiopathic aplastic anemia, were made.