Age-dependent resistance to Cryptosporidium muris (strain MCR) infection in golden hamsters and mice

摘要

An age-dependent aspect of resistance to Cryptosporidium muris (strain MCR) infection was monitored in Syrian golden hamsters, Mesocricetus auratus, at 1-, 5- and 10-week of age and in ICR mice, Mus musculus, at 3-, 12-, and 15-week of age orally inoculated with a single dose of 2×106 oocysts, respectively. The prepatent periods for both animals were similar, independent of age, but the patency was significantly longer in younger hamsters (PC. muris infection is age-related and the innate resistance is independent of age of hamsters, and that both innate and acquired resistance, on the contrary, are irrespective of age of mice.