Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells

Sajin Bae; James Chon; Martha S Field; Patrick J Stover

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Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells

机译：酒精脱氢酶5是HepG2细胞中从头嘌呤生物合成的甲酸酯来源。

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Background: Formate provides one-carbon units for de novo purine and thymidylate (dTMP) synthesis and is produced via both folate-dependent and folate-independent pathways. Folate-independent pathways are mediated by cytosolic alcohol dehydrogenase 5 (ADH5) and mitochondrial aldehyde dehydrogenase 2 (ALDH2), which generate formate by oxidizing formaldehyde. Formate is a potential biomarker of B-vitamin–dependent one-carbon metabolism.

机译：背景：甲酸酯为从头嘌呤和胸苷酸（dTMP）合成提供了一个碳单元，并且通过叶酸依赖性和叶酸依赖性途径生产。叶酸非依赖性途径是由胞质醇脱氢酶5（ADH5）和线粒体醛脱氢酶2（ALDH2）介导的，它们通过氧化甲醛产生甲酸。甲酸盐是依赖B族维生素的一碳代谢的潜在生物标志物。

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《The Journal of Nutrition: Official Organ of the American Institute of Nutrition 》 |2017年第4期| 共7页
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Sajin Bae; James Chon; Martha S Field; Patrick J Stover;
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中图分类营养卫生、食品卫生 ;
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1. Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: Cellular models of de novo purine biosynthesis deficiency disorders [J] . DuvalN., LuhrsK., WilkinsonT.G., Molecular genetics and metabolism . 2013 ,第3期

机译：新生嘌呤生物合成的AdeD和AdeI突变体的遗传和代谢组学分析：新生嘌呤生物合成缺乏症的细胞模型
2. Phenotypes and circadian rhythm in utilization of formate in purine nucleotide biosynthesis de novo in adult humans. [J] . Baggott JE, Gorman GS, Morgan SL Life sciences . 2011 ,第15a16期

机译：成年男子嘌呤核苷酸生物合成中利用甲酸的表型和昼夜节律。
3. Improved synthesis of chiral alcohols with Escherichia coli cells co-expressing pyridine nucleotide transhydrogenase,NADP~+-dependent alcohol dehydrogenase and NAD~+-dependent formate dehydrogenase [J] . Andrea Weckbecker, Werner Hummel Biotechnology Letters . 2004 ,第22期

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4. Construction of L-tert-Leucine Producing Strain by Expressing Heterologous Leucine Dehydrogenase and Formate Dehydrogenase in Escherichia coli [C] . Junzhen Bai, Yajian Song, Xuegang Luo, International conference on applied biotechnology . 2015

机译：在大肠杆菌中表达异源亮氨酸脱氢酶和甲酰胺脱氢酶构建L-叔亮氨酸生产菌株
5. Structural studies of the de novo purine biosynthesis enzyme ATIC and of the natural killer cell receptor NKG2D. [D] . Wolan, Dennis W. 2004

机译：从头嘌呤生物合成酶ATIC和自然杀伤细胞受体NKG2D的结构研究。
6. Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells [O] . Sajin Bae, James Chon, Martha S Field, -1

机译：酒精脱氢酶5是HepG2细胞中从头嘌呤生物合成的甲酸酯来源。
7. Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: Cellular models of de novo purine biosynthesis deficiency disorders [O] . Nathan Duval, Kyleen Luhrs, Terry G. Wilkinson, 2013

机译：De Novo嘌呤生物合成的Aded和Adei突变体的遗传和代谢分析：De Novo嘌呤生物合成缺陷障碍的细胞模型

Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells

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