Low Preoperative Fibrinogen Plasma Concentration Is Associated With Excessive Bleeding After Cardiac Operations

摘要

PatientsLaboratory VariablesClinical ManagementBleeding and TransfusionsStatisticsResultsAll PatientsFibrinogen concentrationBleedingTransfusionsCABG PopulationBleedingTransfusionsData from small selected patient populations suggest that the preoperative plasma concentration of fibrinogen influences postoperative blood loss and red blood cell transfusion after cardiac operations, but there are also conflicting reports. We assessed the importance of preoperative fibrinogen concentration for excessive bleeding and red cell blood transfusion in a large cohort of mixed cardiac surgical patients.MethodsWe included 1,954 cardiac surgical patients in a prospective observational study. The fibrinogen plasma concentration was measured on the day before the operation. Blood loss (mediastinal drain volume) during the first 12 postoperative hours and red blood cell transfusion during the hospital stay were registered and related to fibrinogen concentration with logistic regression models. Excessive bleeding was defined as postoperative blood loss exceeding 1,000 mL/12 hours.ResultsThe preoperative fibrinogen concentration was inversely proportional to the prevalence of excessive bleeding in univariate testing (odds ratio [OR], 0.75; 95% confidence interval [CI], 0.64 to 0.89 per g/L; p?= 0.001) and also in a multiple model adjusted for age, sex, body?mass index, renal function, acuteness of the operation, cardiopulmonary bypass time, clopidogrel use less than 5 days before the operation, and type of operation (OR for fibrinogen, 0.82; 95% CI, 0.69 to 0.97; p?= 0.024).?In contrast, the prevalence of red cell blood transfusion increased with increasing fibrinogen levels in univariate testing (OR, 1.36; 95% CI, 1.24 to 1.49; p < 0.001) but not in a multiple model (OR, 1.10; 95% CI, 0.89 to 1.28; p?= 0.49).ConclusionsPreoperative plasma concentration of fibrinogen is independently associated with excessive bleeding after cardiac operations but not with red blood cell transfusion.CTSNet classification:18Cardiothoracic Anesthesiology:The Annals of Thoracic Surgery CME Program is located online at http://www.annalsthoracicsurgery.org/cme/home. To take the CME activity related to this article, you must have either an STS member or an individual non-member subscription to the journal.Fibrinogen is a key factor in the coagulation cascade. There are conflicting data on whether the preoperative plasma concentration of fibrinogen is associated with postoperative bleeding volume and transfusion after cardiac operations. Although some studies have found a statistically significant correlation with bleeding [