Low Vitamin B12 in Pregnancy Is Associated With Adipose-Derived Circulating miRs Targeting PPARγ and Insulin Resistance

Antonysunil Adaikalakoteswari; Manu Vatish; Mohammad Tauqeer Alam; Sascha Ott; Sudhesh Kumar; Ponnusamy Saravanan

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Low Vitamin B12 in Pregnancy Is Associated With Adipose-Derived Circulating miRs Targeting PPARγ and Insulin Resistance

机译：怀孕时维生素B12的低含量与针对PPARγ和胰岛素抵抗的脂肪衍生的循环miR相关

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AbstractContextLow vitamin B12 during pregnancy is associated with higher maternal obesity, insulin resistance (IR), and gestational diabetes mellitus. B12 is a key cofactor in one-carbon metabolism.

机译：摘要背景怀孕期间维生素B12含量低与孕妇肥胖，胰岛素抵抗（IR）和妊娠糖尿病相关。 B12是单碳代谢中的关键辅助因子。

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《The journal of clinical endocrinology and metabolism》 |2017年第11期|共10页
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Antonysunil Adaikalakoteswari; Manu Vatish; Mohammad Tauqeer Alam; Sascha Ott; Sudhesh Kumar; Ponnusamy Saravanan;
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中图分类代谢病;
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1. Low vitamin B12 in pregnancy is associated with adipose derived circulating miRNAs targeting PPARγ and insulin resistance [J] . A. Antonysunil, M. Vatish, M.T. Alam, Journal of developmental origins of health and disease . 2017,第Suppla1期

机译：怀孕的低维生素B12与靶向PPARγ和胰岛素抵抗的脂肪衍生的循环miRNA相关
2. Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study [J] . C. S. Yajnik, S. S. Deshpande, A. A. Jackson, Diabetologia: clinical and experimental diabetes and metabolism . 2007,第1期

机译：怀孕期间的维生素B12和叶酸浓度以及后代的胰岛素抵抗：浦那母体营养研究
3. Circulating miR-143-3p inhibition protects against insulin resistance in Metabolic Syndrome via targeting of the insulin-like growth factor 2 receptor [J] . Lin Xihua, Tang Shengjie, Gui Weiwei, Translational research: the journal of laboratory and clinical medicine . 2019,第期

机译：循环miR-143-3P抑制通过鉴定胰岛素样生长因子2受体来保护代谢综合征中的胰岛素抵抗力
4. Enhanced Efficacy of Vitamin B12 Targeted Daunorubicin-Linked HPMACopolymers in Preclinical Tumour Models [C] . G. J. Russell-Jones, J. F. McEwan, J. Klaver, Annual meeting exposition of the Controlled Release Society . 2005

机译：在临床前肿瘤模型中靶向维生素B12的柔红霉素连接的HPMACopolymers的功效增强
5. Exploring oral insulin delivery through the vitamin B12 uptake pathway. [D] . Petrus, Amanda K. 2009

机译：探索通过维生素B12摄取途径的口服胰岛素递送。
6. Lower Circulating B12 Is Associated with Higher Obesity and Insulin Resistance during Pregnancy in a Non-Diabetic White British Population [O] . Bridget Ann Knight, Beverley M. Shields, Adam Brook, -1

机译：在非糖尿病的英国白人人群中较低的循环血B12与较高的肥胖和胰岛素抵抗相关
7. Low vitamin B12 in pregnancy is associated with adipose derived circulating miRs targeting PPARγ and insulin resistance [O] . Adaikalakoteswari, A, Vatish, M, Alam, MT, 2017

机译：妊娠期维生素B12含量低与脂肪来源的循环miR靶向PPARγ和胰岛素抵抗有关

Low Vitamin B12 in Pregnancy Is Associated With Adipose-Derived Circulating miRs Targeting PPARγ and Insulin Resistance

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