Laminin-5γ-2 (LAMC2) Is Highly Expressed in Anaplastic Thyroid Carcinoma and Is Associated With Tumor Progression, Migration, and Invasion by Modulating Signaling of EGFR

Manoj Garg; Deepika Kanojia; Ryoko Okamoto; Saket Jain; Vikas Madan; Wenwen Chien; Abhishek Sampath; Ling-Wen Ding; Meng Xuan; Jonathan W. Said; Ngan B. Doan; Li-Zhen Liu; Henry Yang; Sigal Gery; Glenn D. Braunstein; H. Phillip Koeffler

首页> 外文期刊>The journal of clinical endocrinology and metabolism >Laminin-5γ-2 (LAMC2) Is Highly Expressed in Anaplastic Thyroid Carcinoma and Is Associated With Tumor Progression, Migration, and Invasion by Modulating Signaling of EGFR

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Laminin-5γ-2 (LAMC2) Is Highly Expressed in Anaplastic Thyroid Carcinoma and Is Associated With Tumor Progression, Migration, and Invasion by Modulating Signaling of EGFR

机译：层粘连蛋白5γ-2（LAMC2）在间变性甲状腺癌中高表达，并通过调节EGFR信号传导与肿瘤进展，迁移和侵袭相关。

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Context:Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy having no effective treatment. Laminin subunit-γ-2 (LAMC2) is an epithelial basement membrane protein involved in cell migration and tumor invasion and might represent an ideal target for the development of novel therapeutic approaches for ATC.

机译：背景：间变性甲状腺癌（ATC）是一种积极的恶性肿瘤，没有有效的治疗方法。层粘连蛋白亚基-γ-2（LAMC2）是一种上皮基底膜蛋白，参与细胞迁移和肿瘤侵袭，可能代表开发ATC新型治疗方法的理想靶标。

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《The journal of clinical endocrinology and metabolism 》 |2014年第1期| 共11页
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Manoj Garg; Deepika Kanojia; Ryoko Okamoto; Saket Jain; Vikas Madan; Wenwen Chien; Abhishek Sampath; Ling-Wen Ding; Meng Xuan; Jonathan W. Said; Ngan B. Doan; Li-Zhen Liu; Henry Yang; Sigal Gery; Glenn D. Braunstein; H. Phillip Koeffler;
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1. Laminin-5γ-2 (LAMC2) Is Highly Expressed in Anaplastic Thyroid Carcinoma and Is Associated With Tumor Progression, Migration, and Invasion by Modulating Signaling of EGFR [J] . Manoj Garg, Deepika Kanojia, Ryoko Okamoto, The journal of clinical endocrinology and metabolism . 2014 ,第1期

机译：层粘连蛋白5γ-2（LAMC2）在间变性甲状腺癌中高表达，并通过调节EGFR信号传导与肿瘤进展，迁移和侵袭相关。
2. EIF5A2 Is Highly Expressed in Anaplastic Thyroid Carcinoma and Is Associated With Tumor Growth by Modulating TGF-beta Signals [J] . Hao Fengyun, Zhu Qingli, Lu Lingwei, Oncology Research . 2020 ,第4期

机译：EIF5A2在促进型甲状腺癌中高度表达，通过调节TGF-β信号与肿瘤生长有关
3. Histone Deacetylase Inhibition Modulates E-Cadherin Expression and Suppresses Migration and Invasion of Anaplastic Thyroid Cancer Cells [J] . Maria Graziella Catalano, Nicoletta Fortunati, Mariateresa Pugliese, The journal of clinical endocrinology and metabolism . 2012 ,第7期

机译：组蛋白去乙酰化酶抑制调节E-钙黏着蛋白表达并抑制间变性甲状腺癌细胞的迁移和侵袭。
4. ELF-1 Expression in Nasopharyngeal Carcinoma Facilitates Proliferation and Metastasis of Cancer Cells via Modulating CCL2/CCR2 Signaling [C] . Chang-Han Chen International Molecular Medicine Tri-Conference. . 2019

机译：鼻咽癌中的ELF-1表达促进通过调节CCL2 / CCR2信号传导的癌细胞增殖和转移
5. Acquired regulation of MMP-9 gene expression by cooperative integrin α3β1/TGFβ signaling promotes carcinoma progression [D] . Lamar, John M. 2008

机译：协同整联蛋白α3β1/TGFβ信号通路对MMP-9基因表达的获得性调控促进癌症进展
6. Laminin-5γ-2 (LAMC2) Is Highly Expressed in Anaplastic Thyroid Carcinoma and Is Associated With Tumor Progression Migration and Invasion by Modulating Signaling of EGFR [O] . Manoj Garg, Deepika Kanojia, Ryoko Okamoto, -1

机译：层粘连蛋白5γ-2（LAMC2）在间变性甲状腺癌中高表达并通过调节EGFR信号传导与肿瘤进展迁移和侵袭相关。
7. Laminin-5γ-2 (LAMC2) Is Highly Expressed in Anaplastic Thyroid Carcinoma and Is Associated With Tumor Progression, Migration, and Invasion by Modulating Signaling of EGFR [O] . Manoj Garg, Deepika Kanojia, Ryoko Okamoto, 2014

机译：层粘连蛋白-5γ-2（LAMC2）在激动塑化的甲状腺癌中高度表达，通过调节EGFR的信号传导，与肿瘤进展，迁移和侵袭有关

Laminin-5γ-2 (LAMC2) Is Highly Expressed in Anaplastic Thyroid Carcinoma and Is Associated With Tumor Progression, Migration, and Invasion by Modulating Signaling of EGFR

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