Exomic Sequencing of Medullary Thyroid Cancer Reveals Dominant and Mutually Exclusive Oncogenic Mutations in RET and RAS

Nishant Agrawal; Yuchen Jiao; Mark Sausen; Rebecca Leary; Chetan Bettegowda; Nicholas J. Roberts; Sheetal Bhan; Allen S. Ho; Zubair Khan; Justin Bishop; William H. Westra; Laura D. Wood; Ralph H. Hruban; Ralph P. Tufano; Bruce Robinson; Henning Dralle; Sergio P. A. Toledo; Rodrigo A. Toledo; Luc G. T. Morris; Ronald A. Ghossein; James A. Fagin; Timothy A. Chan; Victor E. Velculescu; Bert Vogelstein; Kenneth W. Kinzler; Nickolas Papadopoulos; Barry D. Nelkin; Douglas W. Ball

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Exomic Sequencing of Medullary Thyroid Cancer Reveals Dominant and Mutually Exclusive Oncogenic Mutations in RET and RAS

机译：髓样甲状腺癌的外显子测序揭示了RET和RAS中的主要和相互排斥的致癌突变。

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Context:Medullary thyroid cancer (MTC) is a rare thyroid cancer that can occur sporadically or as part of a hereditary syndrome.

机译：背景：甲状腺髓样癌（MTC）是一种罕见的甲状腺癌，可能偶发或作为遗传综合征的一部分发生。

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《The journal of clinical endocrinology and metabolism》 |2013年第2期|共6页
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Nishant Agrawal; Yuchen Jiao; Mark Sausen; Rebecca Leary; Chetan Bettegowda; Nicholas J. Roberts; Sheetal Bhan; Allen S. Ho; Zubair Khan; Justin Bishop; William H. Westra; Laura D. Wood; Ralph H. Hruban; Ralph P. Tufano; Bruce Robinson; Henning Dralle; Sergio P. A. Toledo; Rodrigo A. Toledo; Luc G. T. Morris; Ronald A. Ghossein; James A. Fagin; Timothy A. Chan; Victor E. Velculescu; Bert Vogelstein; Kenneth W. Kinzler; Nickolas Papadopoulos; Barry D. Nelkin; Douglas W. Ball;
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1. A new therapeutic approach in medullary thyroid cancer treatment: inhibition of oncogenic RET signaling by adenoviral vector-mediated expression of a dominant-negative RET mutant. [J] . Drosten M, Frilling A, Stiewe T, Surgery . 2002,第6期

机译：甲状腺髓样癌的一种新治疗方法：通过腺病毒载体介导的显性负RET突变体的表达抑制致癌性RET信号传导。
2. Whole exome sequencing identifies a germline MET MET mutation in two siblings with hereditary wild‐type RET RET medullary thyroid cancer [J] . Sponziello Marialuisa, Benvenuti Silvia, Gentile Alessandra, Human mutation . 2018,第3期

机译：整体exome测序识别芽髓在两个兄弟姐妹中遇到了遗传性野生型Ret Ret髓质甲状腺癌的突变
3. Correlative analyses of RET RET and RAS mutations in a phase 3 trial of cabozantinib in patients with progressive, metastatic medullary thyroid cancer [J] . Sherman Steven I., Clary Douglas O., Elisei Rossella, Cancer: A Journal of the American Cancer Society . 2016,第24期

机译：Cabozantinib患者在渐进式，转移髓质甲状腺癌患者中的3阶段RET和RAS突变的相关分析
4. PathMEx: Pathway-Based Mutual Exclusivity for Discovering Rare Cancer Driver Mutations [C] . Yahya Bokhari, Tomasz Arodz International Conference on Computational Science and Its Applications . 2021

机译：Pathmex：基于途径的互动术，用于发现稀有癌症司机突变
5. Characterization of Precancerous Mutations in Ulcerative Colitis-Associated Colorectal Cancer and High-Grade Serous Ovarian Cancer via Duplex Sequencing [D] . Baker, Kathryn Terese 2018

机译：溃疡性结肠炎相关大肠癌和高级别浆液性卵巢癌癌前突变的双重测序表征。
6. Exomic Sequencing of Medullary Thyroid Cancer Reveals Dominant and Mutually Exclusive Oncogenic Mutations in RET and RAS [O] . Nishant Agrawal, Yuchen Jiao, Mark Sausen, -1

机译：髓样甲状腺癌的外显子测序揭示了RET和RAS中的主要和相互排斥的致癌突变。
7. Exomic Sequencing of Medullary Thyroid Cancer Reveals Dominant and Mutually Exclusive Oncogenic Mutations in RET and RAS [O] . Nishant Agrawal, Yuchen Jiao, Mark Sausen, 2013

机译：髓质甲状腺癌的突出测序揭示了RET和RAS中的显性和相互独家致癌突变

Exomic Sequencing of Medullary Thyroid Cancer Reveals Dominant and Mutually Exclusive Oncogenic Mutations in RET and RAS

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