Discontinuing Long-Term GH Replacement Therapy—A Randomized, Placebo-Controlled Crossover Trial in Adult GH Deficiency

Helena Filipsson Nystr?m; Edna J. L. Barbosa; Anna G. Nilsson; Lise-Lott Norrman; Oskar Ragnarsson; Gudmundur Johannsson

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Discontinuing Long-Term GH Replacement Therapy—A Randomized, Placebo-Controlled Crossover Trial in Adult GH Deficiency

机译：停止长期GH替代疗法—成人GH缺乏症的一项随机，安慰剂对照的交叉试验

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Context:Adult GH deficiency (GHD) is associated with impaired quality of life (QoL) and increased cardiovascular risk. Continued long-term efficacy in terms of QoL and cardiovascular risk factors has been indicated in open surveillance studies.

机译：背景：成人GH缺乏症（GHD）与生活质量（QoL）受损和心血管风险增加有关。在开放式监测研究中已表明，就生活质量和心血管危险因素而言，长期的持续疗效。

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《The journal of clinical endocrinology and metabolism》 |2012年第9期|共11页
作者
Helena Filipsson Nystr?m; Edna J. L. Barbosa; Anna G. Nilsson; Lise-Lott Norrman; Oskar Ragnarsson; Gudmundur Johannsson;
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1. Discontinuing Long-Term GH Replacement Therapy—A Randomized, Placebo-Controlled Crossover Trial in Adult GH Deficiency [J] . Helena Filipsson Nystr?m, Edna J. L. Barbosa, Anna G. Nilsson, The journal of clinical endocrinology and metabolism . 2012,第9期

机译：停止长期GH替代疗法—成人GH缺乏症的一项随机，安慰剂对照的交叉试验
2. The effect of growth hormone (GH) replacement therapy on sympathetic nerve hyperactivity in hypopituitary adults: a double-blind, placebo-controlled, crossover, short-term trial followed by long-term open GH replacement in hypopituitary adults. [J] . Sverrisdottir YB, Elam M, Caidahl K, Journal of hypertension . 2003,第10期

机译：生长激素（GH）替代疗法对垂体下垂成年人交感神经亢进的影响：一项双盲，安慰剂对照，交叉，短期试验，然后对垂体下垂成年人进行长期开放性GH替代。
3. Results of a global phase 3, randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of sebelipase alfa as an enzyme replacement therapy in children and adults with lysosomal acid lipase deficiency [J] . Burton Barbara Molecular genetics and metabolism . 2015,第2期

机译：一项全球3期，随机，双盲，安慰剂对照试验的结果，评估了sebelipase alfa作为酶替代疗法在溶酶体酸性脂肪酶缺乏症儿童和成人中的功效和安全性
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5. Image-Analysis with Fiji Program on Peripheral Blood Monocular Cells After Consumption of High-Fat, High Carbohydrate Meal with or Without Addition of Spices: A Single-Center Randomized, Blinded, Placebo-Controlled, 4-Arm, 24-hr Acute Crossover Study [D] . Tsai, Meng Fu. 2020

机译：用斐济单眼细胞进行斐济血液单眼细胞的图像分析，用或没有添加香料：单中心随机，盲，安慰剂控制，4臂，24小时急性交叉研究
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机译：红甜菜根汁对中老年/超重和肥胖成年人高脂膳食对血管内皮功能和心脏代谢反应的影响：一项随机双盲安慰剂对照交叉试验
7. Discontinuing Long-Term GH Replacement Therapy—A Randomized, Placebo-Controlled Crossover Trial in Adult GH Deficiency [O] . Helena Filipsson Nyström, Edna J. L. Barbosa, Anna G. Nilsson, 2012

机译：在成年GH缺乏中停止长期GH替代治疗 - A随机，安慰剂控制的交叉试验

Discontinuing Long-Term GH Replacement Therapy—A Randomized, Placebo-Controlled Crossover Trial in Adult GH Deficiency

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