Immunoreactivity Score Using an Anti-sst2A Receptor Monoclonal Antibody Strongly Predicts the Biochemical Response to Adjuvant Treatment with Somatostatin Analogs in Acromegaly

Federico Gatto; Richard A. Feelders; Rob van der Pas; Johan M. Kros; Marlijn Waaijers; Diana Sprij-Mooij; Sebastian J. C. M. M. Neggers; Aart-Jan van der Lelij; Francesco Minuto; Steven W. J. Lamberts; Wouter W. de Herder; Diego Ferone; Leo J. Hofland

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Immunoreactivity Score Using an Anti-sst2A Receptor Monoclonal Antibody Strongly Predicts the Biochemical Response to Adjuvant Treatment with Somatostatin Analogs in Acromegaly

机译：使用抗sst2A受体单克隆抗体的免疫反应评分可以强烈预测肢端肥大症中生长抑素类似物对辅助治疗的生化反应。

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Context:Somatostatin receptor subtype 2 (sst2A) protein expression has been demonstrated to positively correlate with somatostatin analog treatment outcome in GH-secreting adenomas. Recently, a new rabbit monoclonal anti-sst2A antibody (clone UMB-1) has been validated as a reliable method to selectively detect sst2A protein levels in formalin-fixed tissues.

机译：背景：生长抑素受体亚型2（sst2A）蛋白表达已被证明与生长激素分泌腺瘤中生长抑素类似物治疗结果呈正相关。最近，一种新型兔抗sst2A单克隆抗体（克隆UMB-1）已被验证为一种选择性检测福尔马林固定组织中sst2A蛋白水平的可靠方法。

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《The journal of clinical endocrinology and metabolism》 |2013年第1期|共6页
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Federico Gatto; Richard A. Feelders; Rob van der Pas; Johan M. Kros; Marlijn Waaijers; Diana Sprij-Mooij; Sebastian J. C. M. M. Neggers; Aart-Jan van der Lelij; Francesco Minuto; Steven W. J. Lamberts; Wouter W. de Herder; Diego Ferone; Leo J. Hofland;
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1. Low somatostatin receptor subtype 2, but not dopamine receptor subtype 2 expression predicts the lack of biochemical response of somatotropinomas to treatment with somatostatin analogs [J] . WildembergL.E.A., NetoL.V., CostaD.F., Journal of Endocrinological Investigation: Official Journal of the Italian Society of Endocrinology . 2013,第1期

机译：生长抑素受体亚型2较低，但多巴胺受体亚型2较低，这表明生长激素释放瘤对生长激素抑制素类似物的治疗缺乏生化反应
2. Somatostatin analog treatment is associated with an increased sleep latency in patients with long-term biochemical remission of acromegaly. [J] . van-der-Klaauw AA, Pereira AM, van-Kralingen KW, Growth hormone and IGF research: Official journal of the Growth Hormone Research Society and the International IGF Research Society . 2008,第5期

机译：生长抑素类似物的治疗与肢端肥大症的长期生化缓解患者的睡眠潜伏期延长有关。
3. Added Value of Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Predicting Response to Somatostatin Analogs in Acromegaly Patients [J] . Turkish neurosurgery . 2019,第6期

机译：动态对比增强磁共振成像的附加值预测对患者生长抑制素类似物的响应
4. Cloning and expression of a biosimilar chimeric monoclonal antibody directed against the human epidermal growth factor receptor and its production in CHO cells for treatment of colo-rectal cancer. [D] . Motiwala, Hatim Maqbulhusen. 2012

机译：针对人表皮生长因子受体的生物仿制药嵌合单克隆抗体的克隆和表达及其在CHO细胞中的产生，用于治疗结肠直肠癌。
5. Clinical and Radiological Predictors of Biochemical Response to First-Line Treatment With Somatostatin Receptor Ligands in Acromegaly: A Real-Life Perspective [O] . Federica Nista, Giuliana Corica, Lara Castelletti, 2021

机译：对棘手的生长抑制素受体配体的一线治疗生化反应的临床和放射性预测因子：真实的视角
6. Immunoreactivity score using an anti-sst2A receptor monoclonal antibody strongly predicts the biochemical response to adjuvant treatment with somatostatin analogs in acromegaly [O] . Gatto, F. (Federico), Feelders, R.A. (Richard), Pas, R. (Rob) van der, 2013

机译：使用抗sst2A受体单克隆抗体的免疫反应评分强烈预测了肢端肥大症中生长抑素类似物对辅助治疗的生化反应

Immunoreactivity Score Using an Anti-sst2A Receptor Monoclonal Antibody Strongly Predicts the Biochemical Response to Adjuvant Treatment with Somatostatin Analogs in Acromegaly

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