The Efficacy Of Jatropha Multifida In The Management Of Oral Candidiasis: A Preliminary Study

摘要

Background: Oral candidiasis is presently a common problem affecting children in third world countries. This is probably due to the increasing prevalence of human immunodeficiency virus infections, poverty and malnutrition, which predisposes to candida infections. There are anecdotal reports suggesting the efficacy of the Nigerian grown species of Jatropha multifida herbs in the management of oral candidiasis.Aims of the study: To determine the efficacy of Jatropha multifida in the management of oral candidiasis and compare its efficacy with that of oral Nystatin.Subjects and Method: All the clinically detected cases of children with oral candidiasis at the children's outpatient department of the State Hospital, Osogbo and children's welfare clinic of the Wesley Guild Hospital, Ilesa were randomized into either Jatropha multifadum Juice extract therapy or the Nystatin group. The juice extracts from the Jatropha multifada leaves were applied to the tongue and the oral mucosal areas affected by candida lesions as a single application in the patients randomized to this group. Oral Nystatin was administered 4 times a day, for 7 consecutive days to the children randomized to the Nystatin group. Results: A total of 5 patients (3 boys and 2 girls) were studied with their ages ranging from 2 to 10 months. Clearance of the white lesions on the tongue was defined as cure and this was recorded within 24 hours in the patients on Jatropha multifada juice extracts, while those on oral Nystatin showed features of cure at 48 hours.Conclusion: Jatropha multifada is efficacious in the management of oral candidiasis. Compared to oral Nystatin suspension, it has the advantages of acting faster and being efficacious as a single dose. Its use in the management of oral candidiasis is recommended in third world countries where it is easily cultivated and accessible. Introduction Oral candidiasis (thrush) is a fungal infection caused by Candida albicans. This organism is a normal flora and inhabitant of the skin, mouth, vagina and intestinal mucosa. 1 It can be spread to a newborn infant from the mother's birth canal during vaginal delivery. Prolonged use of antibiotics, leading to alteration in the oral flora may also cause thrush. The oral lesions are usually white flaky plaques and they may cover all or part of the tongue, lips, gingival and buccal mucous membranes. Oral candidiasis can be acute in the newborn or chronic in children with nutritional deficiencies or debilitating conditions. 2 The differential diagnoses of thrush include geographical tongue which is an asymptomatic, benign condition that requires no treatment. It is a normal variant of tongue appearance. 3 The tongue being covered with milk can also mimic thrush, however this milk curds can be easily scrapped off from epithelial surfaces. Diagnosis of oral candidiasis can be confirmed by direct microscopic examination and culture of the scrapings from the mucous membranes. Nystatin is the most popular choice of antifungal agent used for the treatment of oral fungal infections among general dental practitioners. 2 Conventionally thrush is treated by the oral administration of 100,000 I.U of Nystatin suspension four times a day for 7 consecutive days. One percent aqueous solution of gential violet is also effective orally and topically, but it is messy.3 Jatropha multifida are small trees or shrubs with smooth gray barks, which exudes whitish colored watery latex when cut 5. Other common names are coral plant and adenoropium multifidum. It normally grows to attain a height between three and seven feet. In addition it grows well in the tropics and can thrive in almost every kind of soil.5 Previous studies conducted in Tanzania have shown that Jatropha Multifida has significant antifugal activity, against many species of Candida, but very little against candida albicans. 6 This study aims to show that the specie of Jatropha multifida cultivated in Nigeria, possess antibiotic activity aga