Estrogen Receptor α and Aromatase Polymorphisms Affect Risk, Prognosis, and Therapeutic Outcome in Men with Castration-Resistant Prostate Cancer Treated with Docetaxel-Based Therapy

Tristan M. Sissung; Romano Danesi; C. Tyler Kirkland; Caitlin E. Baum; Sandra B. Ockers; Erica V. Stein; David Venzon; Douglas K. Price; William D. Figg

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Estrogen Receptor α and Aromatase Polymorphisms Affect Risk, Prognosis, and Therapeutic Outcome in Men with Castration-Resistant Prostate Cancer Treated with Docetaxel-Based Therapy

机译：雌激素受体α和芳香酶多态性影响多西他赛治疗的去势抵抗性前列腺癌男性的风险，预后和治疗结果

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Context:Reactive estrogen species cause genotoxicity and interfere with docetaxel-mediated tubulin polymerization resulting in shortened survival in men with castrate-resistant prostate cancer (CRPC).

机译：背景：反应性雌激素会引起遗传毒性并干扰多西他赛介导的微管蛋白聚合，从而导致去势抵抗性前列腺癌（CRPC）男性的生存期缩短。

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《The journal of clinical endocrinology and metabolism》 |2011年第2期|共5页
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Tristan M. Sissung; Romano Danesi; C. Tyler Kirkland; Caitlin E. Baum; Sandra B. Ockers; Erica V. Stein; David Venzon; Douglas K. Price; William D. Figg;
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1. Phase I study of ixabepilone, mitoxantrone, and prednisone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel-based therapy: a study of the department of defense prostate cancer clinical trials consortium. [J] . Rosenberg JE, Ryan CJ, Weinberg VK, Journal of Clinical Oncology . 2009,第17期

机译：ixabepilone，米托蒽醌和泼尼松在已接受多西他赛治疗的转移性去势抵抗性前列腺癌患者中的I期研究：美国国防部前列腺癌临床试验联盟的一项研究。
2. Aromatase-induced endogenous estrogen promotes tumour metastasis through estrogen receptor-alpha/matrix metalloproteinase 12 axis activation in castration-resistant prostate cancer [J] . Liang Zhixian, Cao Jiasong, Tian Lei, Cancer letters . 2019,第期

机译：芳族酶诱导的内源性雌激素通过雌激素受体-α/基质金属蛋白酶12轴活化在阉割的前列腺癌中促进肿瘤转移
3. Novel therapeutic strategies following docetaxel-based chemotherapy in castration-resistant prostate cancer [J] . Naohiro Fujimoto, Masaki ShiotA_2, Tatsuhiko Kubo, Expert review of clinical pharmacology . 2010,第6期

机译：基于多西他赛的化学疗法治疗去势抵抗性前列腺癌后的新治疗策略
4. Sequencing of Therapies in Men with Castration-Resistant Prostate Cancer [C] . Philip Kantoff Genitourinary Cancers Symposium . 2012

机译：抗阉割前列腺癌的男性疗法测序
5. A comparative study of quality of life in patients with low-and intermediate-risk prostate cancer treated at a single institution: Stereotactic radiotherapy vs. high dose-rate brachytherapy monotherapy vs. high dose-rate brachytherapy boost [D] . Helou, Joelle. 2017

机译：单一机构治疗的中低危前列腺癌患者生活质量的比较研究：立体定向放疗与高剂量率近距离放射疗法单药疗法与高剂量率近距离放射疗法增强
6. Estrogen Receptor α and Aromatase Polymorphisms Affect Risk Prognosis and Therapeutic Outcome in Men with Castration-Resistant Prostate Cancer Treated with Docetaxel-Based Therapy [O] . Tristan M. Sissung, Romano Danesi, C. Tyler Kirkland, -1

机译：雌激素受体α和芳香酶多态性影响多西他赛治疗的去势抵抗性前列腺癌男性的风险预后和治疗结果
7. Estrogen receptor alpha and aromatase polymorphisms affect risk, prognosis, and therapeutic outcome in men with castration-resistant prostate cancer treated with docetaxel-based therapy [O] . SISSUNG TM, DANESI R, KIRKLAND CT, 2011

机译：雌激素受体α和芳香酶多态性影响去势抵抗性前列腺癌男性的风险，预后和治疗结果以多西他赛为基础的疗法治疗的癌症
8. Epidermal Growth Factor (EGF) Receptor Intron 1 CA Repeat Polymorphisms in African-American and Caucasian Males: Influence on Prostate Cancer Risk or Disease Progression and Interaction with Androgen Receptor CAG Repeat Polymorphisms [R] . Moscatello, D. K. 2005

机译：表皮生长因子（EGF）受体内含子1 Ca在非洲裔美国人和高加索人男性中重复多态性：对前列腺癌风险或疾病进展的影响以及与雄激素受体CaG重复多态性的相互作用

Estrogen Receptor α and Aromatase Polymorphisms Affect Risk, Prognosis, and Therapeutic Outcome in Men with Castration-Resistant Prostate Cancer Treated with Docetaxel-Based Therapy

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