Epidermal Growth Factor (EGF) Receptor Intron 1 CA Repeat Polymorphisms in African-American and Caucasian Males: Influence on Prostate Cancer Risk or Disease Progression and Interaction with Androgen Receptor CAG Repeat Polymorphisms

摘要

We are investigating the effect of a polymorphic epidermal growth factor receptor (EGFR) gene intron 1 CA repeat on prostate cancer (CaP) development, alone or in combination with a known androgen receptor gene CAG repeat polymorphism. We will characterize these repeats in DNA from African- American and Caucasian men with CaP. The data will be analyzed for any correlation using both parameters with clinical outcome age of onset, rapid progression, or metastasis. The Human Subjects Protocol was approved by the US Army MRMC HSRRB on 24 November 2003. However, the resignation of the study coordinator at the Cooper Hospital/ University Medical Center last year and the failure of my clinical collaborator to train a new coordinator in a timely manner resulted in further delays in initiating subject recruitment. Fortunately, new clinical collaborators affiliated with Thomas Jefferson University (TJU) have agreed to participate in the study. This site has been approved by both the DOD and the HSRRB has also approved the new Human Subjects Protocol. Subject recruitment at TJU was initiated in mid-February of this year. Since recruitment began, eighty-seven (87) new subjects entered the study, and we anticipate achieving our goal of 113 more (300 total) CaP subjects by mid-2007. A new urologist and study coordinator are now available at cooper Hospital. We have requested a no-cost extension of the grant through June 2007 in order to complete the research.