Mortality in Children Receiving Growth Hormone Treatment of Growth Disorders: Data From the Genetics and Neuroendocrinology of Short Stature International Study

Charmian A Quigley; Christopher J Child; Alan G Zimmermann; Ron G Rosenfeld; Leslie L Robison; Werner F Blum

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Mortality in Children Receiving Growth Hormone Treatment of Growth Disorders: Data From the Genetics and Neuroendocrinology of Short Stature International Study

机译：接受生长激素治疗生长障碍的儿童的死亡率：来自矮身材国际研究的遗传学和神经内分泌学的数据

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AbstractContextAlthough pediatric growth hormone (GH) treatment is generally considered safe for approved indications, concerns have been raised regarding potential for increased risk of mortality in adults treated with GH during childhood.

机译：尽管小儿生长激素（GH）治疗通常被认为对批准的适应症是安全的，但人们对在儿童期接受GH治疗的成年人中增加死亡风险的可能性提出了关注。

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《The journal of clinical endocrinology and metabolism》 |2017年第9期|共11页
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Charmian A Quigley; Christopher J Child; Alan G Zimmermann; Ron G Rosenfeld; Leslie L Robison; Werner F Blum;
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1. Incidence of diabetes mellitus and neoplasia in Japanese short-statured children treated with growth hormone in the Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS) [J] . Susumu Yokoya, Tomonobu Hasegawa, Keiichi Ozono, Clinical Pediatric Endocrinology . 2017,第4期

机译：矮身材国际研究（GeNeSIS）的遗传学和神经内分泌学中，生长激素治疗的日本矮身儿童的糖尿病和肿瘤形成的发生率
2. Growth Hormone Treatment for Short Stature in the USA, Germany and France: 15 Years of Surveillance in the Genetics and Neuroendocrinology of Short-Stature International Study (GeNeSIS) [J] . Pfaeffle Roland, Land Christof, Schoenau Eckhard, Hormone research in p?diatrics . 2018,第3期

机译：美国，德国和法国短地生长激素治疗：15年的遗传学和神经内部病例的监测（创世纪）
3. The Basis for Optimising Growth with Growth Hormone Usage in Children with Idiopathic Short Stature: Analysis of Data from KIGS (Pfizer International Growth Study Database) [J] . Michael B. Ranke, Anders Lindberg, on behalf of the KIGS International Board Hormone research in p?diatrics . 2011,第S3期

机译：特发性矮小儿童使用生长激素优化生长的基础：KIGS数据分析（辉瑞国际生长研究数据库）
4. Discussion on Childhood Growth and Later Outcomes, Policy Implications and Treatment of Short Stature [C] . Aryeh D. Stein Nestlé Nutrition Workshop . 2013

机译：浅谈儿童增长及后续结果，政策影响和近地位的治疗
5. Periconceptional treatment with growth hormone alters fetal growth and development in sheep. [D] . Koch, Jill Marie. 2008

机译：用生长激素进行孕周治疗会改变绵羊的胎儿生长发育。
6. Incidence of diabetes mellitus and neoplasia in Japanese short-staturedchildren treated with growth hormone in the Genetics and Neuroendocrinology of ShortStature International Study (GeNeSIS) [O] . Susumu Yokoya, Tomonobu Hasegawa, Keiichi Ozono, 2017

机译：日本矮型人群糖尿病和肿瘤形成的发生率生长激素治疗的儿童矮小的遗传和神经内分泌学身材国际研究（GeNeSIS）
7. Comparison of response to 2-years’ growth hormone treatment in children with isolated growth hormone deficiency, born small for gestational age, idiopathic short stature, or multiple pituitary hormone deficiency: combined results from two large observational studies [O] . Lee Peter A, Sävendahl Lars, Oliver Isabelle, 2012

机译：孤立性生长激素缺乏症，小胎龄，特发性矮小或多发性垂体激素缺乏症儿童对2年期生长激素治疗的反应比较：两项大型观察性研究的合并结果

Mortality in Children Receiving Growth Hormone Treatment of Growth Disorders: Data From the Genetics and Neuroendocrinology of Short Stature International Study

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