id="Par1" class="Para">With the advancement and improvement of new sequencing technology, next-generation sequencing (NGS) has been applied increasingly in cancer genomics research fields. More recently, NGS has been adopted in clinical oncology to advance personalized treatment of cancer. NGS is utilized to novel diagnostic and rare cancer mutations, detection of translocations, inversions, insertions and deletions, detection of copy number variants, detect familial cancer mutation carriers, provide the molecular rationale for appropriate targeted, therapeutic and prognostic. NGS holds many advantages, such as the ability to fully sequence all types of mutations for a large number of genes (hundreds to thousands) and the sensitivity, speed in a single test at a relatively low cost compared to be other sequencing modalities. Here we described the technology, methods and applications that can be immediately considered and some of the challenges that lie ahead.
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机译：id =“ Par1” class =“ Para”>随着新测序技术的进步和改进，下一代测序（NGS）已越来越多地应用于癌症基因组学研究领域。最近，NGS已在临床肿瘤学中被采用来推进癌症的个性化治疗。 NGS可用于新颖的诊断性癌症和罕见癌症突变，易位，倒位，插入和缺失的检测，拷贝数变异的检测，家族性癌症突变携带者的检测，为适当的靶向，治疗和预后提供分子基础。 NGS具有许多优势，例如能够对大量基因（数百至数千个）对所有类型的突变进行完全测序，并且与其他测序方法相比，以相对较低的成本在一次测试中具有较高的灵敏度，速度。在这里，我们描述了可以立即考虑的技术，方法和应用，以及即将面临的一些挑战。
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