Influence of C(60) fullerene on the ischemia-reperfusion injury in the skeletal muscle of rat limb: mechanokinetic and biochemical analysis

摘要

Influence of the pristine Csub60/sub fullerene aqueous colloidal solution (Csub60/subFAS) on the ischemia-reperfusion injury in the skeletal muscle of rat limb was studied. Skeletal muscle damage effects were induced by 3 h lasting vascular ischemia. The impact of Csub60/subFAS was studied after its intramuscular injection immediately after 1 h of reperfusion at different doses, namely: 1, 2 and 3 mg/kg of body weight. Changes in the mechanokinetic parameters of ischemic skeletal muscle contraction at different modes of functioning and biochemical parameters of blood were used as markers of ischemic injury, and analyzed in detail under action of Csub60/subFAS. The obtained results indicate on great promise of use of C60FAS to reduce the consequences of ischemic muscle trauma.