Reply to “Phase II prospective randomized trial of weight loss prior to radical prostatectomy”

摘要

We commend Henning et al. [1] and their randomized controlled trial of a weight loss intervention (WLI) among prostate cancer patients in the presurgical setting. Abbreviated study periods and complicated logistics make these trials challenging. We speak from experience, since we completed a trial of similar design [2,3,4]. While Henning et al. discussed our trial [1,2,3], our findings were not presented, possibly due to publication overlap [4]. Both trials were undertaken with the same scientific premise: weight loss would slow tumor proliferation and reduce biomarkers of insulin signaling, inflammation, and androgenic control. Thus, we submit this letter to compare and contrast these two pioneering efforts.