Author summary To understand synaptic mechanisms underlying neuronal computations, a fundamental approach is to use voltage clamp to measure the dynamics of excitatory and inhibitory input conductances. Due to the space clamp effect, the measured conductance in general deviates from the local input conductance on the dendrites, hence its biological interpretation is questionable, as we demonstrate in this work. We further propose the concept of effective conductance that is proportional to the local input conductance on the dendrites and reflects directly the synaptic impact on spike generation, and develop a framework to determine the effective conductance reliably. Our work provides a biologically plausible metric for elucidating synaptic influence on neuronal computation under the constraint of the space clamp effect.
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