The importance of mechanical constraints for proper polarization and psuedo-cleavage furrow generation in the early Caenorhabditis elegans embryo

摘要

Author summary Polarization, whereby molecules and proteins are asymmetrically distributed throughout the cell, is a vital process for many cellular functions. In the early C. elegans embryo the asymmetric distribution of cell cytoskeleton during the initiation of polarization leads to asymmetric contractions which are higher in the anterior and lower in the posterior of a cell. The C. elegans embryo is surrounded by a rigid body, the eggshell, which functions in numerous cell processes. We investigate the structural support of eggshell during the establishment phase by tracking the moving cell surface. We incorporate protein dynamics involved in polarization into the membrane evolution. We conclude that eggshell might have a role in cell polarization by preventing the distortion of cell surface.