Cardiovascular regulation and body temperature: evidence from a nap vs. sleep deprivation randomized controlled trial.

摘要

In this study we set out to understand is sleep fragmentationaffects the cardiovascular regulation and circadian variability ofcore body temperature more or less than sleep deprivation.50 healthy men (age 29.0±3.1 years; BMI 24.3±2.1 kg/m2)participated in a 3-day study that included one adaptative nightand one experimental night involving randomization to: sleepdeprivation (SD) and sleep fragmentation (SF). The evaluationincluded hemodynamic parameters, measures of the spectralanalysis of heart rate and blood pressure variability, and thesensitivity of arterial baroreflex function. Core body temperature(CBT) was measured with a telemetric system. SF affects heartrate (61.9±5.6 vs. 56.2±7.6, p0.01) and stroke index(52.7±11.1 vs. 59.8±12.2, p0.05) with significant changes inthe activity of the ANS (LF-sBP: 6.0±5.3 vs. 3.4±3.7, p0.05;HF-sBP: 1.8±1.8 vs. 1.0±0.7, p0.05; LF-dBP: 5.9±4.7 vs.3.5±3.2, p0.05) more than SD. Post hoc analysis revealed thatafter SD mean value of CBT from 21:30 to 06:30 was significantlyhigher compared to normal night’s sleep and SF. In healthy menSF affects the hemodynamic and autonomic changes more thanSD. Sympathetic overactivity is the proposed underlyingmechanism.