The effect of combined diet containing n-3 polyunsaturated fatty acids and silymarin on metabolic syndrome in rats.

摘要

The risk of development of metabolic syndrome can be increasedby hypertriglyceridemia. A search for effective therapy isa subject of considerable attention. Therefore, our hypothesis isthat the fish oil (containing polyunsaturated fatty acids;n-3 PUFA) in a combination with silymarin can more effectivelyprotect against hypertriglyceridemia-induced metabolicdisturbances. The study was conducted using a uniquenon-obese strain of rats with hereditary hypertriglyceridemia anaccepted model of metabolic syndrome. Adult male rats weretreated with n-3 PUFA (300 mg/kg/day) without or with 1 %micronized silymarin in a diet for 4 weeks. The treatment withthe diet containing n-3 PUFA and silymarin significantly reducedconcentrations of serum triglycerides (-45 %), total cholesterol(-18 %), non-esterified fatty acids (-33 %), and ectopic lipidaccumulation in skeletal muscle (-35 %) compared to controls.In addition, an increase in Abcg5 and Abcg8 mRNA expression(as genes affecting lipid homeostasis) as well as in proteincontent of ABCG5 (+78 %) and ABCG8 (+232 %) transportershave been determined in the liver of treated rats. Our findingssuggest that this combined diet could be used in the preventionof hypertriglyceridemia-induced metabolic disorders.