PHOSPHONYLATION OF INOSINE WITH SODIUM DIPHOSPHONATE IN AQUEOUS SOLUTION

摘要

Phosphonylation of inosine (Ino) has been achieved using inorganic diphosphonate (DP) in aqueous solution. The optimum condition for the phosphonylation of Ino with DP is Ino : DP = 1 : 10, pH 11 and 10 °C. 2′-Phosphonylinosine and 3′-phosphonylinosine were synthesized with the total yield of more than 95 %. The phosphonylated products of Ino were stable at 10 °C and pH 9. The reaction mechanism of Ino with DP was discussed.