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Encapsulation of Natural Polyphenolic Compounds; a Review

机译:天然多酚化合物的包封;回顾

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摘要

Natural polyphenols are valuable compounds possessing scavenging properties towards radical oxygen species, and complexing properties towards proteins. These abilities make polyphenols interesting for the treatment of various diseases like inflammation or cancer, but also for anti-ageing purposes in cosmetic formulations, or for nutraceutical applications. Unfortunately, these properties are also responsible for a lack in long-term stability, making these natural compounds very sensitive to light and heat. Moreover, polyphenols often present a poor biodisponibility mainly due to low water solubility. Lastly, many of these molecules possess a very astringent and bitter taste, which limits their use in food or in oral medications. To circumvent these drawbacks, delivery systems have been developed, and among them, encapsulation would appear to be a promising approach. Many encapsulation methods are described in the literature, among which some have been successfully applied to plant polyphenols. In this review, after a general presentation of the large chemical family of plant polyphenols and of their main chemical and biological properties, encapsulation processes applied to polyphenols are classified into physical, physico-chemical, chemical methods, and other connected stabilization methods. After a brief description of each encapsulation process, their applications to polyphenol encapsulation for pharmaceutical, food or cosmetological purposes are presented.
机译:天然多酚是有价值的化合物,具有对自由基氧物种的清除性能,以及对蛋白质的络合性能。这些能力使多酚在治疗各种疾病(例如炎症或癌症)中很有趣,而且在化妆品配方中或用于营养保健品中也可达到抗衰老的目的。不幸的是,这些性质也造成缺乏长期稳定性,使得这些天然化合物对光和热非常敏感。此外,多酚通常表现出较差的生物适应性,这主要是由于低水溶性。最后,这些分子中的许多具有非常涩涩的味道,这限制了它们在食品或口服药物中的使用。为了克服这些缺点,已经开发了递送系统,其中,封装似乎是一种有前途的方法。文献中描述了许多包囊方法,其中一些已成功地应用于植物多酚。在这篇综述中,在对植物多酚的大型化学家族及其主要化学和生物学特性进行了总体介绍之后,应用于多酚的封装工艺可分为物理,物理化学,化学方法和其他关联的稳定化方法。在简要介绍每个封装过程之后,介绍它们在多酚封装中的应用,以用于制药,食品或美容。

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